Department of Research & Scientific Services, Schülke & Mayr GmbH, Norderstedt, Germany; Faculty of Mechanical Engineering, Kiel University of Applied Sciences, Kiel, Germany.
Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
J Hosp Infect. 2021 May;111:180-183. doi: 10.1016/j.jhin.2021.01.031. Epub 2021 Feb 11.
The outbreak of the SARS-CoV-2 pandemic is triggering a global health emergency alert. Until vaccination becomes available, a bundle of effective preventive measures is desperately needed. Recent research is indicating the relevance of aerosols in the spread of SARS-CoV-2. Thus, in this study commercially available antiseptic mouthwashes based on the active ingredients chlorhexidine digluconate and octenidine dihydrochloride (OCT) were investigated regarding their efficacy against SARS-CoV-2 using the European Standard 14476. Based on the requirement of EN 14476 in which reduction of at least four decimal logarithms (≥4 log) of viral titre is requested to state efficacy, the OCT-based formulation was found to be effective within a contact time of only 15 s against SARS-CoV-2. Based on this in-vitro data the OCT mouthwash thus constitutes an interesting candidate for future clinical studies to prove its effectiveness in a potential prevention of SARS-CoV-2 transmission by aerosols.
SARS-CoV-2 大流行的爆发引发了全球卫生紧急警报。在疫苗接种可用之前，急需一整套有效的预防措施。最近的研究表明，气溶胶在 SARS-CoV-2 的传播中起重要作用。因此，本研究采用欧洲标准 14476，针对市售的以葡萄糖酸氯己定和盐酸奥替尼啶（OCT）为有效成分的抗菌漱口水，研究其对 SARS-CoV-2 的功效。根据 EN 14476 的要求，需要将病毒滴度降低至少四个十进制对数（≥4 log）才能表明有效，OCT 为基础的配方在 15 秒的接触时间内对 SARS-CoV-2 有效。基于这些体外数据，OCT 漱口水因此成为未来临床研究的一个有趣候选，以证明其在通过气溶胶预防 SARS-CoV-2 传播方面的有效性。
