Chongqing Research Center for Pharmaceutical Engineering, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, College of Pharmacy, Chongqing Medical University, No.1, Yixueyuan Road, Yuzhong District, Chongqing 400016, PR China.
Experimental Teaching and Management Center, Chongqing Medical University, Chongqing, 400016, PR China.
Colloids Surf B Biointerfaces. 2021 Apr;200:111596. doi: 10.1016/j.colsurfb.2021.111596. Epub 2021 Feb 4.
The combination of photothermal therapy (PTT) and chemotherapy is a promising strategy to overcome the shortcomings of monotherapy. For the first time, we designed a self-coated nanoparticle formed by mesoporous polydopamine (MPDA) core and polydopamine (PDA) shell, which was used to load docetaxel and modified with hyaluronic acid (HA). The obtained nanoparticle can achieve targeted drug delivery and further exert the synergistic effect of PTT and chemotherapy. The MPDA core has high drug loading due to mesopores, and the PDA shell can prevent the drug from releasing in the non-target-site because of the pH-sensitivity of the PDA. Compared with other PDA coated nanoparticle, self-coated nanoparticle has a simpler composition and can avoid the potential toxicity caused by the introduction of other materials. Experimental results showed that it had good photothermal conversion ability both in vivo and in vitro, and could be actively targeted into tumor cells through HA-mediated targeting. Under laser irradiation, it ablated the tumors. Simple ingredient and preparation, good compatibility and obvious therapeutic effect make it have a broad application prospect in tumor therapy.
光热疗法（PTT）和化疗的联合是克服单药治疗缺点的一种很有前途的策略。我们首次设计了一种由介孔聚多巴胺（MPDA）核和聚多巴胺（PDA）壳组成的自包覆纳米粒子，用于负载多西他赛并进行透明质酸（HA）修饰。所得纳米粒子可以实现靶向药物传递，并进一步发挥 PTT 和化疗的协同作用。MPDA 核由于介孔而具有高载药量，而 PDA 壳由于 PDA 的 pH 敏感性可以防止药物在非靶部位释放。与其他 PDA 包覆的纳米粒子相比，自包覆纳米粒子具有更简单的组成，并且可以避免引入其他材料潜在的毒性。实验结果表明，它在体内和体外均具有良好的光热转换能力，并且可以通过 HA 介导的靶向作用主动靶向肿瘤细胞。在激光照射下，它可以消融肿瘤。简单的成分和制备、良好的相容性和明显的治疗效果使其在肿瘤治疗中有广阔的应用前景。
