The Fourth Affiliated Hospital, Zhejiang University School of Medicine, 322000, Yiwu, Zhejiang, People's Republic of China.
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, People's Republic of China.
J Nanobiotechnology. 2021 Nov 24;19(1):387. doi: 10.1186/s12951-021-01131-9.
Polydopamine (PDA), which is derived from marine mussels, has excellent potential in early diagnosis of diseases and targeted drug delivery owing to its good biocompatibility, biodegradability, and photothermal conversion. However, when used as a solid nanoparticle, the application of traditional PDA is restricted because of the low drug-loading and encapsulation efficiencies of hydrophobic drugs. Nevertheless, the emergence of mesoporous materials broaden our horizon. Mesoporous polydopamine (MPDA) has the characteristics of a porous structure, simple preparation process, low cost, high specific surface area, high light-to-heat conversion efficiency, and excellent biocompatibility, and therefore has gained considerable interest. This review provides an overview of the preparation methods and the latest applications of MPDA-based nanodrug delivery systems (chemotherapy combined with radiotherapy, photothermal therapy combined with chemotherapy, photothermal therapy combined with immunotherapy, photothermal therapy combined with photodynamic/chemodynamic therapy, and cancer theranostics). This review is expected to shed light on the multi-strategy antitumor therapy applications of MPDA-based nanodrug delivery systems.
聚多巴胺（PDA）源自海洋贻贝，具有良好的生物相容性、生物可降解性和光热转换性能，在疾病的早期诊断和靶向药物输送方面具有巨大的潜力。然而，当用作固体纳米颗粒时，由于疏水性药物的载药和包封效率低，传统 PDA 的应用受到限制。然而，介孔材料的出现拓宽了我们的视野。介孔聚多巴胺（MPDA）具有多孔结构、制备工艺简单、成本低、比表面积高、光热转换效率高、生物相容性好等特点，因此引起了广泛的关注。本文综述了 MPDA 基纳米药物输送系统的制备方法及最新应用（化疗联合放疗、光热治疗联合化疗、光热治疗联合免疫治疗、光热治疗联合光动力/化学动力学治疗以及癌症治疗）。本文有望为基于 MPDA 的纳米药物输送系统的多策略抗肿瘤治疗应用提供启示。
