Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Curr Med Sci. 2021 Feb;41(1):51-57. doi: 10.1007/s11596-021-2317-2. Epub 2021 Feb 13.
Coronavirus disease 2019 (COVID-19) occurs in the influenza season and has become a global pandemic. The present study aimed to examine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection with influenza A virus (IAV) in an attempt to provide clues for the antiviral interventions of co-infected patients. We described two patients who were co-infected with SARS-CoV-2 and IAV treated at Wuhan Union Hospital, China. In addition, we performed a review in PubMed, Web of Science and CNKI (from January 1 up to November 1, 2020) with combinations of the following key words: "COVID-19, SARS-COV-2, influenza A and co-infection". A total of 28 co-infected patients were enrolled in the analysis. Of the 28 patients, the median age was 54.5 years (IQR, 34.25-67.5) and 14 cases (50.0%) were classified as severe types. The most common symptoms were fever (85.71%), cough (82.14%) and dyspnea (60.71%). Sixteen patients had lymphocytopenia on admission and 23 patients exhibited abnormal radiological changes. The median time from symptom onset to hospital admission was 4 days (IQR, 3-6), and the median time of hospital stay was 14 days (IQR, 8.5-16.75). In conclusion, patients with SARS-COV-2 and IAV co-infection were similar to those infected with SARS-COV-2 alone in symptoms and radiological images. SARS-COV-2 co-infection with IAV could lead to more severe clinical condition but did not experience longer hospital stay compared with patients infected with SARS-COV-2 alone.
新型冠状病毒病 2019（COVID-19）发生在流感季节，已成为全球大流行。本研究旨在研究严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）与甲型流感病毒（IAV）的合并感染，试图为合并感染患者的抗病毒干预提供线索。我们描述了两例在中国武汉协和医院治疗的 SARS-CoV-2 和 IAV 合并感染患者。此外，我们在 PubMed、Web of Science 和中国知网（CNKI）上进行了检索，检索时间为 2020 年 1 月 1 日至 11 月 1 日，检索词组合为“COVID-19、SARS-COV-2、influenza A 和 co-infection”。共纳入 28 例合并感染患者进行分析。28 例患者的中位年龄为 54.5 岁（IQR，34.25-67.5），14 例（50.0%）为重型。最常见的症状是发热（85.71%）、咳嗽（82.14%）和呼吸困难（60.71%）。入院时 16 例患者淋巴细胞减少，23 例患者影像学异常。从症状出现到住院的中位时间为 4 天（IQR，3-6），中位住院时间为 14 天（IQR，8.5-16.75）。总之，SARS-CoV-2 和 IAV 合并感染患者的症状和影像学表现与单纯感染 SARS-CoV-2 患者相似。与单纯感染 SARS-CoV-2 患者相比，SARS-CoV-2 合并 IAV 感染可能导致更严重的临床状况，但住院时间没有延长。
