Huang Yanhao, Li Shumin, Ye Wenjie, Wang Haoyun, Su Jun, Gao Lijuan, Shi Ruohu, Mou Xinyi, Leng Sean Xiao, Xiao Chanchan, Chen Guobing
The Sixth Affiliated Hospital of Jinan University (Dongguan Eastern Central Hospital), School of Medicine, Jinan University, Dongguan 523000, China.
Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou 510632, China.
Vaccines (Basel). 2025 Apr 21;13(4):431. doi: 10.3390/vaccines13040431.
As age increases, the immune function of elderly individuals gradually decreases, increasing their susceptibility to infectious diseases. Therefore, further research on common viral infections in the elderly population, especially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses, is crucial for scientific progress. This review delves into the genetic structure, infection mechanisms, and impact of coinfections with these two viruses and provides a detailed analysis of the reasons for the increased susceptibility of elderly individuals to dual viral infections. We evaluated the clinical manifestations in elderly individuals following coinfections, including complications in the respiratory, gastrointestinal, nervous, and cardiovascular systems. Ultimately, we have summarized the current strategies for the prevention, diagnosis, and treatment of SARS-CoV-2 and influenza coinfections in older adults. Through these studies, we aim to reduce the risk of dual infections in elderly individuals and provide a scientific basis for the prevention, diagnosis, and treatment of age-related viral diseases, thereby improving their health status.
随着年龄的增长，老年人的免疫功能逐渐下降，增加了他们对传染病的易感性。因此，进一步研究老年人群中的常见病毒感染，尤其是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和流感病毒，对科学进步至关重要。本综述深入探讨了这两种病毒的基因结构、感染机制以及合并感染的影响，并详细分析了老年人对双重病毒感染易感性增加的原因。我们评估了老年人合并感染后的临床表现，包括呼吸、胃肠、神经和心血管系统的并发症。最终，我们总结了目前预防、诊断和治疗老年人SARS-CoV-2和流感合并感染的策略。通过这些研究，我们旨在降低老年人双重感染的风险，为与年龄相关的病毒性疾病的预防、诊断和治疗提供科学依据，从而改善他们的健康状况。
