Department of Obstetrics and Gynecology, Firat University, School of Medicine, Elazig, Turkey.
Department of Obstetrics and Gynecology, Adana Numune Training and Research Hospital, Adana, Turkey.
J Perinat Med. 2021 Feb 15;49(5):614-618. doi: 10.1515/jpm-2020-0419. Print 2021 Jun 25.
We aimed to compare gender difference on sizes of some structures in the brain of normal male and female fetuses between 20 and 22 week gestations.
A total of 300 female and 300 male singleton pregnancies with low risk were included in the study. Biparietal diameter, head circumference, transcerebellar diameter, cisterna magna, nuchal fold thickness, anterior and posterior horn of lateral ventricles, length and width of cavum septum pellucidum were measured transabdominally. Mean±SD values were calculated and comparison of measurements were done between male and female fetuses. Kolmogorov-Smirnov and independent samples -test were used for statistical analysis. A value of p<0.05 were accepted as statistically significant.
We determined statistically significant difference in sizes of some structures of the brain of male and female fetuses. Mean±SD value of cavum septi pellucidi width was 3.38±0.61 and 3.85±0.96 in female and males, respectively (p<0.05). Male fetuses were also found to have larger anterior (1.92±0.30 vs. 1.58±0.26, p<0.0001) and posterior horn of lateral ventricles (6.00±0.87 vs. 5.53±1.17, p<0.05).
Difference in sizes of some structures of the brain starts in fetal life. This finding may be important in evaluating the intracranial structures more precisely. These results may also give a contribution to the understanding physiological and pathologic differences between males and females.
我们旨在比较 20-22 孕周正常男性和女性胎儿脑内某些结构的大小的性别差异。
本研究共纳入 300 名女性和 300 名男性单胎低危妊娠。经腹部测量双顶径、头围、小脑横径、脑池、颈项透明层厚度、侧脑室前角和后角、透明隔腔长和宽。计算平均值±标准差，并比较男性和女性胎儿的测量值。采用 Kolmogorov-Smirnov 和独立样本 t 检验进行统计分析。p<0.05 被认为具有统计学意义。
我们确定了男性和女性胎儿脑内某些结构大小存在统计学显著差异。女性和男性胎儿透明隔腔宽的平均值±标准差分别为 3.38±0.61 和 3.85±0.96（p<0.05）。还发现男性胎儿的侧脑室前角（1.92±0.30 比 1.58±0.26，p<0.0001）和后角（6.00±0.87 比 5.53±1.17，p<0.05）也更大。
脑内某些结构大小的差异在胎儿期就开始了。这一发现可能对更精确地评估颅内结构具有重要意义。这些结果也可能有助于理解男性和女性之间的生理和病理差异。
