阳性和阳性晚期非小细胞肺癌患者的不同临床特征。
Different clinical features between patients with -positive and -positive advanced non-small cell lung cancer.
机构信息
Department of Oncology, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China.
Department of Pathology, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China.
出版信息
J Int Med Res. 2021 Feb;49(2):300060521993643. doi: 10.1177/0300060521993643.
OBJECTIVE
To compare the baseline clinical characteristics between patients with -positive and -positive advanced non-small cell lung cancer (NSCLC), and the correlations of these subtypes with the distribution of metastases.
METHODS
We compared the clinical characteristics and imaging features of patients with -positive and -positive NSCLC using statistical methods.
RESULTS
Data for 232 patients were analyzed. Compared with -positive NSCLC, -positive NSCLC was more likely to occur in women (71% vs 53%), and primary lesions ≤3 cm were more common in patients with -positive compared with -positive NSCLC (58% vs 37%). There was no significant difference in the distribution of metastases between the two groups. Subgroup analysis within the -positive group showed that, compared with primary lesions >3 cm, primary lesions ≤3 cm were more likely to present as peripheral tumors (72% vs 43%) and more likely to exhibit non-solid density (44% vs 4%).
CONCLUSIONS
Although -positive and -positive NSCLCs show similar clinical features, the differences may help clinicians to identify patients requiring further genotyping at initial diagnosis.
目的
比较阳性和阳性晚期非小细胞肺癌（NSCLC）患者的基线临床特征，并分析这些亚型与转移分布的相关性。
方法
我们使用统计学方法比较了阳性和阳性 NSCLC 患者的临床特征和影像学特征。
结果
共分析了 232 例患者的数据。与阳性 NSCLC 相比，阳性 NSCLC 更常见于女性（71% vs 53%），且阳性 NSCLC 患者的原发肿瘤≤3cm 更为常见（58% vs 37%）。两组患者的转移分布无显著差异。在阳性组内的亚组分析中，与原发肿瘤>3cm 相比，原发肿瘤≤3cm 更可能表现为外周肿瘤（72% vs 43%），并且更可能表现为非实性密度（44% vs 4%）。
结论
尽管阳性和阳性 NSCLC 具有相似的临床特征，但这些差异可能有助于临床医生在初始诊断时识别需要进一步进行基因分型的患者。
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