SARS-CoV-2 在临床表现、转归和治疗方面的性别差异。
Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2.
机构信息
Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.
Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT, USA.
出版信息
Clin Ther. 2021 Mar;43(3):557-571.e1. doi: 10.1016/j.clinthera.2021.01.015. Epub 2021 Jan 16.
Abstract
This review describes the sex and gender differences in COVID-19 presentation, treatment, and outcomes. We discuss the differences between the sexes in susceptibility to infection, the role of sex chromosomes on the body's immunologic response and the influence of hormones on the body's response to the virus. Additionally, the sex differences in clinical and laboratory presentation, complications of infection and outcomes, as well as differences in response to treatment and prevention are reviewed.
摘要
这篇综述描述了 COVID-19 在临床表现、治疗和结局方面的性别差异。我们讨论了感染易感性方面的性别差异、性染色体在身体免疫反应中的作用，以及激素对身体对病毒反应的影响。此外，还回顾了临床和实验室表现、感染并发症和结局方面的性别差异，以及对治疗和预防的反应差异。
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