2024年1月至5月新疆住院严重急性呼吸道感染和流感样疾病多病原体感染流行病学特征的回顾性研究

Retrospective study on the epidemiological characteristics of multi-pathogen infections of hospitalized severe acute respiratory tract infection and influenza-like illness in Xinjiang from January to May 2024.

作者信息

Huang Jia, Ma Xin, Wu Haiyan, Awuxi Hundezi, Zhang Xuan, Chen Yuan, Alitengsaier Nigedeli, Li Quanxi

机构信息

Institute of Pathogenic Biological Detection, Xinjiang Center for Disease Control and Prevention, Urumqi, Xinjiang, China.

Xinjiang Center for Disease Control and Prevention, No. 380, Jianquan 1st Street, Tianshan District, Urumqi, 830002, Xinjiang, China.

出版信息

BMC Infect Dis. 2025 Feb 23;25(1):252. doi: 10.1186/s12879-025-10654-7.

DOI:10.1186/s12879-025-10654-7

PMID:39988694

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11849332/

Abstract

BACKGROUND

Acute respiratory tract infections are very common and can be caused by many pathogens. The aim of this study was to understand the characteristics of multi-pathogen infections of respiratory tract infections during the seasonal changes in winter and spring in Xinjiang.

METHODS

Throat swab samples were collected from 2791 patients with influenza-like illness (ILI) and hospitalized severe acute respiratory tract infection (SARI) in Xinjiang from January 2024 to May 2024 for multi-pathogen detection. Then, the infection frequency of pathogens and their distribution characteristics in different months, genders, regions and case classifications were analyzed.

RESULTS

The positive infection rate of pathogens in 2791 patients was 48.30% (1348/2791). The proportion of patients infected with respiratory pathogens in the 0-9 age group was the highest. Of all pathogens detected, MP was most common in positive patients (22.03%). The highest frequency of multiple infections was SPn. RSV, FluA and FluB were the main infectious pathogens in January and February. The number of RV, HPIV and MP infections showed an increasing trend from January to May. Compared to female patients, male patients are more likely to be infected with ADV and SPn. Compared with hospitalized SARI patients, outpatient and emergency ILI patients were more susceptible to infection with ADV and FluB. However, hospitalized SARI patients were more susceptible to infection with RSV and MP. The positive infected patients mainly came from northern Xinjiang (60.83%). Compared with other regions, the proportion of ADV positive patients in northern Xinjiang was higher.

CONCLUSION

This study revealed the distribution characteristics of pathogen infection in patients with respiratory tract infections in different months, genders, regions and case classifications during the seasonal changes of winter and spring in Xinjiang for the first time, which is helpful to formulate more effective treatment strategies and preventive measures.

CLINICAL TRIAL NUMBER

not applicable.

摘要

背景

急性呼吸道感染非常常见，可由多种病原体引起。本研究旨在了解新疆冬春季节变化期间呼吸道感染多病原体感染的特征。

方法

收集2024年1月至2024年5月新疆2791例流感样疾病（ILI）患者和住院严重急性呼吸道感染（SARI）患者的咽拭子样本进行多病原体检测。然后，分析病原体的感染频率及其在不同月份、性别、地区和病例分类中的分布特征。

结果

2791例患者的病原体阳性感染率为48.30%（1348/2791）。0-9岁年龄组呼吸道病原体感染患者比例最高。在所有检测到的病原体中，MP在阳性患者中最常见（22.03%）。多重感染频率最高的是SPn。RSV、FluA和FluB是1月和2月的主要感染病原体。RV、HPIV和MP感染数量从1月到5月呈上升趋势。与女性患者相比，男性患者更易感染ADV和SPn。与住院SARI患者相比，门诊和急诊ILI患者更容易感染ADV和FluB。然而，住院SARI患者更容易感染RSV和MP。阳性感染患者主要来自新疆北部（60.83%）。与其他地区相比，新疆北部ADV阳性患者比例更高。