免疫介导的改变和紊乱在 ALS 疾病中的作用。
The role of immune-mediated alterations and disorders in ALS disease.
机构信息
La Jolla Institute for Immunology, Center for Autoimmunity and Inflammation, La Jolla, CA 92037, USA.
Department of Neurology, Columbia University; New York State Psychiatric Institute, New York, NY 10032, USA; Departments of Psychiatry and Pharmacology, Columbia University; New York State Psychiatric Institute, New York, NY 10032, USA.
出版信息
Hum Immunol. 2021 Mar;82(3):155-161. doi: 10.1016/j.humimm.2021.01.017. Epub 2021 Feb 12.
Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that leads to neuronal death in the brain and spinal cord. Over the last decades, evidence has emerged regarding the functional diversity of astrocytes, microglia, and T cells in the central nervous system (CNS), and the role of neuroinflammation in ALS. In this review, we summarize current knowledge regarding neuroinflammation in ALS, both at the level of specific molecular pathways and potential cellular pathways as well as outline questions about the immune mechanisms involved in ALS pathogenesis.
摘要
肌萎缩侧索硬化症（ALS）是一种进行性神经退行性疾病，导致大脑和脊髓中的神经元死亡。在过去的几十年中，有关星形胶质细胞、小胶质细胞和 T 细胞在中枢神经系统（CNS）中的功能多样性以及神经炎症在 ALS 中的作用的证据已经出现。在这篇综述中，我们总结了目前关于 ALS 中神经炎症的知识，包括特定分子途径和潜在细胞途径的水平，并概述了与 ALS 发病机制相关的免疫机制的问题。
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