Riphah Institute of Pharmaceutical Sciences, Riphah International University (RIU), 7th Avenue Sector G7/4, Islamabad, Pakistan.
Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
Pak J Pharm Sci. 2020 Jul;33(4):1451-1458.
Present research work discloses new and novel synthesis of metal complexes (Fe, Cu, Zn, Sb and Sn) of 3, 4, 5-trihydroxybenzoic acid derivative containing aniline moiety with substitution at C-7 position of 3, 4, 5-trihydroxybenzoic acid in order to enhance its biological activities by coupling therapeutic values of transition metals as well. In vitro antibacterial and antifungal activities of these compounds has been performed by using agar diffusion method against different bacterial and fungal strains. The free radical scavenging assay was performed by using 2, 2-diphenyl-1-picryl-hydrazyl (DPPH). Cytotoxic action of compounds was assessed by utilizing the standard MTT (3-[4, 5-dimethylthiazole-2-yl]-2, 5-diphenyl-tetrazolium bromide) colorimetric assay. The structure of newly synthesized complexes were confirmed by using IR and HNMR spectral analysis.
目前的研究工作揭示了一种新的、新颖的方法，用于合成含有苯胺部分的 3,4,5-三羟基苯甲酸衍生物的金属配合物（Fe、Cu、Zn、Sb 和 Sn），其中 3,4,5-三羟基苯甲酸在 C-7 位置上有取代基，目的是通过结合过渡金属的治疗价值来提高其生物活性。通过琼脂扩散法，对这些化合物进行了针对不同细菌和真菌菌株的体外抗菌和抗真菌活性测试。通过使用 2,2-二苯基-1-苦基肼（DPPH）进行自由基清除测定。通过使用标准的 MTT（3-[4,5-二甲基噻唑-2-基]-2,5-二苯基四唑溴盐）比色法评估化合物的细胞毒性作用。通过 IR 和 HNMR 光谱分析确认了新合成的配合物的结构。
