Helsing K J, Sandler D P, Comstock G W, Chee E
Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD.
Am J Epidemiol. 1988 May;127(5):915-22. doi: 10.1093/oxfordjournals.aje.a114894.
A private census of Washington County, Maryland, in 1963 obtained information on smoking habits of all adults in the census, and death certificates of all residents who died in the next 12 years were coded for underlying cause of death and matched to the census. Among the white population aged 25 and over, 4,162 men and 14,873 women had never smoked. In this group, death rates from arteriosclerotic heart disease were significantly higher among men (relative risk (RR) = 1.31, 95% confidence interval (CI) 1.1-1.6) and women (RR = 1.24, 95% CI 1.1-1.4) who lived with smokers in 1963, after adjustment for age, marital status, years of schooling, and quality of housing. Among women, the relative risk increased significantly (p less than 0.005) with increasing level of exposure; among men, there was little evidence of a dose-response relation. The relative risks for nonsmokers who lived with smokers were greatest among both men and women who were younger than age 45 in 1963, but the number of deaths in these groups was small, and confidence intervals were broad. These results suggest a small but measurable risk for arteriosclerotic heart disease among nonsmokers who live with smokers.
1963年,对马里兰州华盛顿县进行了一次私人普查,获取了普查中所有成年人的吸烟习惯信息,并对接下来12年里所有居民的死亡证明按潜在死因进行编码,使其与普查信息相匹配。在25岁及以上的白人中,有4162名男性和14873名女性从不吸烟。在这一组中,在对年龄、婚姻状况、受教育年限和住房质量进行调整后,1963年与吸烟者共同生活的男性(相对风险(RR)=1.31,95%置信区间(CI)1.1 - 1.6)和女性(RR = 1.24,95%CI 1.1 - 1.4)的动脉硬化性心脏病死亡率显著更高。在女性中,相对风险随着暴露水平的增加而显著增加(p小于0.005);在男性中,几乎没有剂量反应关系的证据。1963年与吸烟者共同生活的不吸烟者的相对风险在45岁以下的男性和女性中最高,但这些组中的死亡人数较少,置信区间较宽。这些结果表明,与吸烟者共同生活的不吸烟者患动脉硬化性心脏病的风险虽小但可测量。