Palmer William C, Cholerton Brenna A, Zabetian Cyrus P, Montine Thomas J, Grabowski Thomas J, Rane Swati
Department of Radiology, University of Washington Medical Center, Seattle, WA, United States.
Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States.
Front Neurol. 2021 Jan 28;11:594213. doi: 10.3389/fneur.2020.594213. eCollection 2020.
Recently, the cerebellum's role in Parkinson's disease (PD) has been highlighted. Therefore, this study sought to test the hypothesis that functional connectivity (FC) between cerebellar and cortical nodes of the resting-state networks differentiates PD patients from controls by scanning participants at rest using functional magnetic resonance imaging (fMRI) and investigating connectivity of the cerebellar nodes of the resting-state networks. Sixty-two PD participants off medication for at least 12 h and 33 normal controls (NCs) were scanned at rest using blood oxygenation level-dependent fMRI scans. Motor and cognitive functions were assessed with the Movement Disorder Society's Revision of the Unified Parkinson's Disease Rating Scale III and Montreal Cognitive Assessment, respectively. Connectivity was investigated with cerebellar seeds defined by Buckner's 7-network atlas. PD participants had significant differences in FC when compared to NC participants. Most notably, PD patients had higher FC between cerebellar nodes of the somatomotor network (SMN) and the corresponding cortical nodes. Cognitive functioning was differentially associated with connectivity of the cerebellar SMN and dorsal attention network. Further, cerebellar connectivity of frontoparietal and default mode networks correlated with the severity of motor function. Our study demonstrates altered cerebello-cortical FC in PD, as well as an association of this FC with PD-related motor and cognitive disruptions, thus providing additional evidence for the cerebellum's role in PD.
最近，小脑在帕金森病（PD）中的作用受到了关注。因此，本研究旨在验证以下假设：通过使用功能磁共振成像（fMRI）对静息状态下的参与者进行扫描，并研究静息状态网络中小脑节点的连通性，静息状态网络中小脑与皮质节点之间的功能连通性（FC）可区分PD患者与对照组。使用基于血氧水平依赖的fMRI扫描对62名至少停药12小时的PD参与者和33名正常对照（NC）进行静息状态扫描。分别使用运动障碍协会修订的统一帕金森病评定量表III和蒙特利尔认知评估量表评估运动和认知功能。使用由巴克纳7网络图谱定义的小脑种子点来研究连通性。与NC参与者相比，PD参与者在FC方面存在显著差异。最值得注意的是，PD患者在躯体运动网络（SMN）的小脑节点与相应皮质节点之间具有更高的FC。认知功能与小脑SMN和背侧注意网络的连通性存在差异相关。此外，额顶叶网络和默认模式网络的小脑连通性与运动功能的严重程度相关。我们的研究证明了PD患者小脑-皮质FC的改变，以及这种FC与PD相关的运动和认知障碍之间的关联，从而为小脑在PD中的作用提供了额外的证据。
