Liu Qing, Shi ZhongYan, Wang Kexin, Liu Tiantian, Funahashi Shintaro, Wu Jinglong, Zhang Jian
Laboratory for Brain Science and Neurotechnology, School of Life Sciences, Beijing Institute of Technology, Beijing, China.
Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing, China.
Front Comput Neurosci. 2022 May 26;16:891384. doi: 10.3389/fncom.2022.891384. eCollection 2022.
Previous studies have demonstrated a close relationship between early Parkinson's disease and functional network abnormalities. However, the pattern of brain changes in the early stages of Parkinson's disease has not been confirmed, which has important implications for the study of clinical indicators of Parkinson's disease. Therefore, we investigated the functional connectivity before and after treatment in patients with early Parkinson's disease, and further investigated the relationship between some topological properties and clinicopathological indicators. We included resting state-fMRI (rs-fMRI) data from 27 patients with early Parkinson's disease aged 50-75 years from the Parkinson's Disease Progression Markers Initiative (PPMI). The results showed that the functional connectivity of 6 networks, cerebellum network (CBN), cingulo_opercular network (CON), default network (DMN), fronto-parietal network (FPN), occipital network (OCC), and sensorimotor network (SMN), was significantly changed. Compared to before treatment, the main functional connections were concentrated in the CBN after treatment. In addition, the coefficients of these nodes have also changed. For betweenness centrality (BC), the FPN showed a significant improvement in treatment ( < 0.001). In conclusion, the alteration of functional networks in early Parkinson's patients is critical for clarifying the mechanisms of early diagnosis of the disease.
先前的研究已经证实早期帕金森病与功能网络异常之间存在密切关系。然而，帕金森病早期阶段大脑变化的模式尚未得到证实，这对帕金森病临床指标的研究具有重要意义。因此，我们研究了早期帕金森病患者治疗前后的功能连接性，并进一步探究了一些拓扑属性与临床病理指标之间的关系。我们纳入了来自帕金森病进展标记物倡议组织（PPMI）的27例年龄在50 - 75岁的早期帕金森病患者的静息态功能磁共振成像（rs - fMRI）数据。结果显示，小脑网络（CBN）、扣带回 - 脑岛网络（CON）、默认网络（DMN）、额顶叶网络（FPN）、枕叶网络（OCC）和感觉运动网络（SMN）这6个网络的功能连接性发生了显著变化。与治疗前相比，治疗后主要功能连接集中在CBN。此外，这些节点的系数也发生了变化。对于中介中心性（BC），FPN在治疗后有显著改善（<0.001）。总之，早期帕金森病患者功能网络的改变对于阐明该疾病早期诊断的机制至关重要。
