Tipping P G, Campbell D A, Boyce N W, Holdsworth S R
From Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Australia.
Am J Pathol. 1988 May;131(2):206-12.
Alveolar macrophage accumulation and interstitial fibrin deposition are prominent in adult respiratory distress syndrome and chronic interstitial lung diseases. The role of alveolar macrophages in the initiation of fibrin deposition and lung injury in these diseases is uncertain. Expression of procoagulant activity by these cells may provide evidence of macrophage activation and involvement in the initiation of lung fibrin deposition. An experimental model of hyperoxia-induced lung injury in rats was studied for assessment of the relationship of lung injury, fibrin deposition, and alveolar macrophage procoagulant activity. Lung injury was assessed histologically and functionally, and the accumulation of inflammatory cells was quantified by bronchoalveolar lavage. Pulmonary injury, manifested by increased capillary permeability, developed progressively during exposure to hyperoxia and was associated with significant augmentation of the procoagulant activity of alveolar macrophages early in the disease. This increase preceded the accumulation of polymorphonuclear leukocytes. Alveolar macrophage procoagulant activity had functional characteristics consistent with tissue factor. These studies provide evidence of early alveolar macrophage activation in acute hyperoxic lung injury in rats and suggest a role for procoagulant activity in the development of interstitial fibrin deposition.
肺泡巨噬细胞积聚和间质纤维蛋白沉积在成人呼吸窘迫综合征和慢性间质性肺疾病中较为显著。肺泡巨噬细胞在这些疾病中纤维蛋白沉积和肺损伤起始过程中的作用尚不确定。这些细胞促凝活性的表达可能为巨噬细胞激活及参与肺纤维蛋白沉积起始过程提供证据。研究了大鼠高氧诱导肺损伤的实验模型，以评估肺损伤、纤维蛋白沉积和肺泡巨噬细胞促凝活性之间的关系。通过组织学和功能评估肺损伤，并通过支气管肺泡灌洗对炎症细胞的积聚进行定量。肺损伤表现为毛细血管通透性增加，在高氧暴露期间逐渐发展，并且在疾病早期与肺泡巨噬细胞促凝活性的显著增强相关。这种增加先于多形核白细胞的积聚。肺泡巨噬细胞促凝活性具有与组织因子一致的功能特征。这些研究为大鼠急性高氧肺损伤中早期肺泡巨噬细胞激活提供了证据，并提示促凝活性在间质纤维蛋白沉积发展中的作用。
