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Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Is Associated with Indigenous American Ancestry in Latin American Women.人表皮生长因子受体 2 阳性乳腺癌与拉丁裔美洲裔妇女的本土美洲原住民血统相关。
Cancer Res. 2020 May 1;80(9):1893-1901. doi: 10.1158/0008-5472.CAN-19-3659. Epub 2020 Apr 3.
2
Latin American Study of Hereditary Breast and Ovarian Cancer : A Genomic Epidemiology Approach.拉丁美洲遗传性乳腺癌和卵巢癌研究:一种基因组流行病学方法。
Front Oncol. 2019 Dec 20;9:1429. doi: 10.3389/fonc.2019.01429. eCollection 2019.
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Breast Cancer Screening Among Women by Nativity, Birthplace, and Length of Time in the United States.按出生地、出生国家和在美国居住时间对女性进行乳腺癌筛查
Natl Health Stat Report. 2019 Oct(129):1-15.
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Breast cancer statistics, 2019.乳腺癌统计数据,2019 年。
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Cancer Epidemiol Biomarkers Prev. 2019 Dec;28(12):1968-1976. doi: 10.1158/1055-9965.EPI-19-0799. Epub 2019 Sep 23.
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A systematic review of the international prevalence of mutation in breast cancer.乳腺癌基因突变国际患病率的系统评价。
Clin Epidemiol. 2019 Jul 11;11:543-561. doi: 10.2147/CLEP.S206949. eCollection 2019.
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The Role of Acculturation and Social Capital in Access to Health Care: A Meta-study on Hispanics in the US.《文化适应和社会资本在获得医疗保健方面的作用:对美国西班牙裔的元研究》。
J Community Health. 2019 Dec;44(6):1224-1252. doi: 10.1007/s10900-019-00692-z.
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Genetic Epidemiology of Breast Cancer in Latin America.拉丁美洲乳腺癌的遗传流行病学。
Genes (Basel). 2019 Feb 18;10(2):153. doi: 10.3390/genes10020153.
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The National Institute on Minority Health and Health Disparities Research Framework.国家少数民族健康与健康差异研究所研究框架。
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西班牙裔/拉丁裔女性的乳腺癌健康差异

Breast Cancer Health Disparities in Hispanics/Latinas.

作者信息

Serrano-Gomez Silvia J, Sanabria-Salas Maria Carolina, Fejerman Laura

机构信息

Grupo de investigación en biología del cáncer, Instituto Nacional de Cancerología, Bogotá, Colombia.

Subdirección de Investigaciones - Instituto Nacional de Cancerología, Bogotá, Colombia.

出版信息

Curr Breast Cancer Rep. 2020 Sep;12(3):175-184. doi: 10.1007/s12609-020-00370-3. Epub 2020 May 28.

DOI:10.1007/s12609-020-00370-3
PMID:33584971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7879708/
Abstract

PURPOSE OF THE REVIEW

Breast cancer incidence and mortality rates are lower in some Hispanic/Latino subpopulations compared to Non-Hispanic White women. However, studies suggest that the risk of breast cancer-specific mortality is higher in US Hispanics/Latinas. In this review we summarized current knowledge on factors associated with breast cancer incidence and risk of mortality in women of Hispanic/Latino origin.

RECENT FINDINGS

Associative studies have proposed a multiplicity of factors likely contributing to differences in breast cancer incidence and survival between population groups, including socioeconomic/sociodemographic factors, lifestyle choices as well as access to and quality of care. Reports of association between global genetic ancestry overall as well as subtype-specific breast cancer risk among Hispanic/Latinas suggest that incidence and subtype distribution could result from differential exposure to environmental and lifestyle related factors correlated with genetic ancestry as well as germline genetic variation.

SUMMARY

Hispanic/Latino in the United States have been largely underrepresented in cancer research. It is important to implement inclusive programs that facilitate the access of this population to health services and that also include education programs for the community on the importance of screening. In addition, it is important to continue promoting the inclusion of Hispanics/Latinos in genomic studies that allow understanding the biological behavior of this disease in the context of all human genetic diversity.

摘要

综述目的

与非西班牙裔白人女性相比,某些西班牙裔/拉丁裔亚人群体的乳腺癌发病率和死亡率较低。然而,研究表明,美国西班牙裔/拉丁裔女性的乳腺癌特异性死亡风险更高。在本综述中,我们总结了目前关于西班牙裔/拉丁裔女性乳腺癌发病率和死亡风险相关因素的知识。

最新发现

关联研究提出了多种可能导致不同人群乳腺癌发病率和生存率差异的因素,包括社会经济/社会人口学因素、生活方式选择以及医疗服务的可及性和质量。关于西班牙裔/拉丁裔整体全球遗传血统以及特定亚型乳腺癌风险之间关联的报告表明,发病率和亚型分布可能是由于与遗传血统以及种系基因变异相关的环境和生活方式相关因素的差异暴露所致。

总结

在美国,西班牙裔/拉丁裔在癌症研究中的代表性一直很低。实施包容性项目很重要,这些项目要便于该人群获得医疗服务,还要包括针对社区的筛查重要性教育项目。此外,继续推动将西班牙裔/拉丁裔纳入基因组研究也很重要,这有助于在所有人类遗传多样性的背景下理解这种疾病的生物学行为。