Serrano-Gomez Silvia J, Sanabria-Salas Maria Carolina, Fejerman Laura
Grupo de investigación en biología del cáncer, Instituto Nacional de Cancerología, Bogotá, Colombia.
Subdirección de Investigaciones - Instituto Nacional de Cancerología, Bogotá, Colombia.
Curr Breast Cancer Rep. 2020 Sep;12(3):175-184. doi: 10.1007/s12609-020-00370-3. Epub 2020 May 28.
Breast cancer incidence and mortality rates are lower in some Hispanic/Latino subpopulations compared to Non-Hispanic White women. However, studies suggest that the risk of breast cancer-specific mortality is higher in US Hispanics/Latinas. In this review we summarized current knowledge on factors associated with breast cancer incidence and risk of mortality in women of Hispanic/Latino origin.
Associative studies have proposed a multiplicity of factors likely contributing to differences in breast cancer incidence and survival between population groups, including socioeconomic/sociodemographic factors, lifestyle choices as well as access to and quality of care. Reports of association between global genetic ancestry overall as well as subtype-specific breast cancer risk among Hispanic/Latinas suggest that incidence and subtype distribution could result from differential exposure to environmental and lifestyle related factors correlated with genetic ancestry as well as germline genetic variation.
Hispanic/Latino in the United States have been largely underrepresented in cancer research. It is important to implement inclusive programs that facilitate the access of this population to health services and that also include education programs for the community on the importance of screening. In addition, it is important to continue promoting the inclusion of Hispanics/Latinos in genomic studies that allow understanding the biological behavior of this disease in the context of all human genetic diversity.
与非西班牙裔白人女性相比,某些西班牙裔/拉丁裔亚人群体的乳腺癌发病率和死亡率较低。然而,研究表明,美国西班牙裔/拉丁裔女性的乳腺癌特异性死亡风险更高。在本综述中,我们总结了目前关于西班牙裔/拉丁裔女性乳腺癌发病率和死亡风险相关因素的知识。
关联研究提出了多种可能导致不同人群乳腺癌发病率和生存率差异的因素,包括社会经济/社会人口学因素、生活方式选择以及医疗服务的可及性和质量。关于西班牙裔/拉丁裔整体全球遗传血统以及特定亚型乳腺癌风险之间关联的报告表明,发病率和亚型分布可能是由于与遗传血统以及种系基因变异相关的环境和生活方式相关因素的差异暴露所致。
在美国,西班牙裔/拉丁裔在癌症研究中的代表性一直很低。实施包容性项目很重要,这些项目要便于该人群获得医疗服务,还要包括针对社区的筛查重要性教育项目。此外,继续推动将西班牙裔/拉丁裔纳入基因组研究也很重要,这有助于在所有人类遗传多样性的背景下理解这种疾病的生物学行为。