伊朗人群中VEGF -2578C/A基因多态性与结直肠癌风险之间无关联。
Lack of association between VEGF -2578C/A polymorphism and risk of colorectal cancer in an Iranian population.
作者信息
Savabkar Sanaz, Zali Neda, Hadizadeh Mahrooyeh, Tavangarroosta Shabnam, Young Chris, Shojaeian Fateme, Ebrahimi Nastaran, Ashrafian Bonab Maziar, Rezvani Hamid, Shalileh Farzaneh, Nazemalhosseini-Mojarad Ehsan
机构信息
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Centre, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
School of Medicine, University of Sunderland, City Campus, Chester Road, Sunderland, SR1 3SD, UK.
出版信息
Gastroenterol Hepatol Bed Bench. 2020 Winter;13(Suppl1):S47-S52.
AIM
Here, we evaluated the VEGF gene -2578C/A polymorphism as a potential susceptibility factor in colorectal cancer (CRC) occurrence amongst Iranian CRC patients.
BACKGROUND
Vascular endothelial growth factor (VEGF) is a key regulatory factor in angiogenesis which plays essential roles in the development of malignancy in colorectal cancer (CRC), as the third most prevalent cancer worldwide.
METHODS
VEGF -2578C/A polymorphism was evaluated in 200 CRC patients and 200 healthy control subjects via restriction fragment length polymorphism analysis.
RESULTS
The frequencies of CC, AC and AA genotypes among CRC patients were 22.5%, 51% and 26.5%, respectively, with their respective genotype frequencies at 16%, 54% and 30% in control cohorts (P=0.247). The A allele frequency among the case group was 52% and for control group, it was 57%. C allele frequency in case and control groups was 48% and 43%, respectively (p=0.156). No significant association was observed (p=0.990) between this polymorphism and CRC stage.
CONCLUSION
Our findings provide limited support for the hypothesis that the -2578C/A VEGF are associated with increased risk of colorectal cancer in Iranian colorectal cancer patients and suggest instead that meta data studies, which have previously relied upon populations definitions such as 'Asian', should more specifically take into account country of origin when associating prognostic value to a given genotype.
目的
在此，我们评估血管内皮生长因子（VEGF）基因-2578C/A多态性作为伊朗结直肠癌（CRC）患者结直肠癌发生潜在易感性因素的情况。
背景
血管内皮生长因子（VEGF）是血管生成中的关键调节因子，在全球第三大常见癌症——结直肠癌（CRC）的恶性肿瘤发展中起重要作用。
方法
通过限制性片段长度多态性分析对200例CRC患者和200例健康对照者进行VEGF -2578C/A多态性评估。
结果
CRC患者中CC、AC和AA基因型的频率分别为22.5%、51%和26.5%，对照组中其各自的基因型频率分别为16%、54%和30%（P = 0.247）。病例组中A等位基因频率为52%，对照组为57%。病例组和对照组中C等位基因频率分别为48%和43%（p = 0.156）。未观察到该多态性与CRC分期之间存在显著关联（p = 0.990）。
结论
我们的研究结果为-2578C/A VEGF与伊朗结直肠癌患者结直肠癌风险增加相关这一假说提供了有限支持，并表明之前依赖“亚洲人”等人群定义的荟萃数据分析，在将预后价值与特定基因型相关联时应更具体地考虑原产国。
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