血管内皮生长因子-2578C/A多态性与结直肠癌风险：一项荟萃分析。

Vascular endothelial growth factor -2578C/A polymorphism and colorectal cancer risk: A meta-analysis.

作者信息

Wang Lei, Ji Shan, Cheng Zeneng

机构信息

Institute of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.

出版信息

J Res Med Sci. 2015 Aug;20(8):811-7. doi: 10.4103/1735-1995.168406.

DOI:10.4103/1735-1995.168406

PMID:26664430

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4652316/

Abstract

BACKGROUND

The effects of the vascular endothelial growth factor (VEGF) gene -2578C/A polymorphism on colorectal cancer (CRC) risk have been investigated in some studies; however, the results of these studies were conflicting and ambiguous. Therefore, we aimed to do a meta-analysis to investigate the association of VEGF -2578C/A polymorphisms with CRC risk from all eligible case-control studies published to date.

MATERIALS AND METHODS

An electronic search of the PubMed, Embase and Medline was performed. Retrieve terms were utilized as following: ("VEGF a" [MeSH Terms]) and ("polymorphism, genetic" [MeSH Terms]) and ("colorectal neoplasms" [MeSH Terms]). The association between VEGF -2578C/A polymorphisms with CRC risk was calculated with odds ratios (ORs) and their corresponding 95% of confidence intervals (CIs), and stratified analysis was also conducted with respect to ethnicity.

RESULTS

A comprehensive meta-analysis of eight studies, including 2312 cases and 2308 controls was performed in this work. Combined analysis revealed that a significant association between the VEGF -2578C/A polymorphism with CRC risk was identified in three comparison models including C allele versus A allele (OR = 0.85, 95% CI 0.75-0.97, P = 0.02), AA versus CA + CC (OR = 1.28, 95% CI 1.09-1.51, P = 0.003), and AA versus CC (OR = 0.77, 95% CI 0.64-0.93, P = 0.006). Moreover, a similar result was obtained in the subgroup analysis that comparison models of C allele versus. A allele (OR = 0.85, 95% CI 0.76-0.95, P = 0.004), AA versus CA + CC (OR = 1.31, 95% CI 1.09-1.57, P = 0.004), and AA versus CC (OR = 0.73, 95% CI 0.59-0.90, P = 0.004) was confirmed to be associated with CRC risk in Caucasian.

CONCLUSION

It has been proved that the C allele versus A allele, AA versus CA + CC, and AA versus CC comparison models of VEGF -2578C/A polymorphism might be risk factors for CRC, but further studies with larger sample sizes are required to make a better assessment of above association.

摘要

背景

一些研究已经探讨了血管内皮生长因子（VEGF）基因-2578C/A多态性对结直肠癌（CRC）风险的影响；然而，这些研究的结果相互矛盾且不明确。因此，我们旨在进行一项荟萃分析，以研究VEGF -2578C/A多态性与迄今为止发表的所有符合条件的病例对照研究中的CRC风险之间的关联。

材料与方法

对PubMed、Embase和Medline进行电子检索。检索词如下使用：（“VEGF a”[医学主题词]）和（“多态性，遗传的”[医学主题词]）和（“结直肠肿瘤”[医学主题词]）。用比值比（OR）及其相应的95%置信区间（CI）计算VEGF -2578C/A多态性与CRC风险之间的关联，并按种族进行分层分析。

结果

在这项工作中对八项研究进行了全面的荟萃分析，包括2312例病例和2308例对照。综合分析显示，在三个比较模型中确定VEGF -2578C/A多态性与CRC风险之间存在显著关联，包括C等位基因与A等位基因（OR = 0.85，95%CI 0.75 - 0.97，P = 0.02）、AA与CA + CC（OR = 1.28，95%CI 1.09 - 1.51，P = 0.003）以及AA与CC（OR = 0.77，95%CI 0.64 - 0.93，P = 0.006）。此外，在亚组分析中也得到了类似结果，即C等位基因与A等位基因（OR = 0.85，95%CI 0.76 - 0.95，P = 0.004）、AA与CA + CC（OR = 1.31，95%CI 1.09 - 1.57，P = 0.004）以及AA与CC（OR = 0.73，95%CI 0.59 - 0.90，P = 0.004）的比较模型被证实与白种人中的CRC风险相关。