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用于婴儿按摩的脂质体包裹微量营养素强化身体油干预措施的开发与实施:预防儿童微量营养素缺乏的创新理念。

Development and Implementation of Liposomal Encapsulated Micronutrient Fortified Body Oil Intervention for Infant Massage: An Innovative Concept to Prevent Micronutrient Deficiencies in Children.

作者信息

Apte Aditi, Lubree Himangi, Kapoor Mudra, Juvekar Sanjay, Banerjee Rinti, Bavdekar Ashish

机构信息

Vadu Rural Health Program, King Edward Memorial Hospital Research Centre, Pune, India.

Nanomedicine Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.

出版信息

Front Public Health. 2021 Jan 25;8:567689. doi: 10.3389/fpubh.2020.567689. eCollection 2020.

Abstract

Indian communities have the ancient cultural practice of gentle oil massage for infants which has been shown to play a beneficial role in neuro-motor development. The concept of incorporating nanosized liposomes of micronutrients (i.e., iron, folate, vitamin B12, and vitamin D) in the body oil leverages this practice for transdermal supplementation of essential micro-nutrients. This paper describes the experience of developing an intervention in the form of body oil containing nanosized liposomes of iron and micro-nutrients built on the social context of infant oil massage using a theory of change approach. The process of development of the intervention has been covered into stages such as design, decide and implement. The design phase describes how the idea of nanosized liposomal encapsulated micronutrient fortified (LMF) body oil was conceptualized and how its feasibility was assessed through initial formative work in the community. The decide phase describes steps involved while scaling up technology from laboratory to community level. The implementation phase describes processes while implementing the intervention of LMF oil in a community-based randomized controlled study. Overall, the theory of change approach helps to outline the various intermediate steps and challenges while translating novel technologies for transdermal nutrient fortification to community level. In our experience, adaptation in the technology for large scale up, formative work and pilot testing of innovation at community level were important processes that helped in shaping the innovation. Meticulous mapping of these processes and experiences can be a useful guide for translating similar innovations.

摘要

印度社区有着为婴儿进行轻柔油浴按摩的古老文化习俗,事实证明这对神经运动发育有益。将微量营养素(即铁、叶酸、维生素B12和维生素D)的纳米脂质体融入身体油中的概念,利用了这种习俗来进行必需微量营养素的经皮补充。本文描述了基于婴儿油浴按摩的社会背景,采用变革理论方法开发一种含有铁和微量营养素纳米脂质体的身体油形式干预措施的经验。干预措施的开发过程分为设计、决策和实施等阶段。设计阶段描述了纳米脂质体包裹微量营养素强化(LMF)身体油的概念是如何形成的,以及如何通过在社区开展的初步形成性工作评估其可行性。决策阶段描述了将技术从实验室扩大到社区层面所涉及的步骤。实施阶段描述了在一项基于社区的随机对照研究中实施LMF油干预措施的过程。总体而言,变革理论方法有助于勾勒出将经皮营养强化新技术转化到社区层面时的各种中间步骤和挑战。根据我们的经验,扩大技术规模时的调整、社区层面的形成性工作和创新试点测试是有助于塑造创新的重要过程。对这些过程和经验进行细致梳理可为类似创新的转化提供有用指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7bd/7874153/4633b7e5e49a/fpubh-08-567689-g0001.jpg

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