Ksander G A
Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, CA.
Ann Plast Surg. 1988 Mar;20(3):215-24. doi: 10.1097/00000637-198803000-00004.
Silicone rubber miniprostheses known to be associated with a high rate of experimental capsule contracture were implanted subcutaneously in rats. Prostheses were coated either with 2 layers of collagen cross-linked with formaldehyde or with 1 layer of collagen cross-linked with glutaraldehyde. Noncoated prostheses were implanted as controls. Contracture was defined as grossly observable distortion of the implant mounds from round to avoid. Capsules were examined histologically at explant at 255 days. In the control group with no coating present capsules formed very early in 100% of the implants. The group with a 2-layer, formaldehyde-treated collagen coat demonstrated the greatest total surface area covered with coating, the least degree of capsule formation, the lowest rate of contracture (7%), and the longest onset. The group with a single layer of collagen treated with glutaraldehyde showed an intermediate coverage of coating, an intermediate degree of capsule formation, an intermediate contracture rate (50%), and an intermediate time of onset. These observations confirm earlier results by showing a correlation between intact collagen coating and absence of capsule formation, and also further demonstrate a significant reduction in the rate of capsule contracture for collagen-coated implants.
已知与实验性包膜挛缩高发生率相关的硅橡胶微型假体被皮下植入大鼠体内。假体要么涂有两层经甲醛交联的胶原蛋白，要么涂有一层经戊二醛交联的胶原蛋白。未涂层的假体作为对照植入。挛缩定义为植入物隆起从圆形明显扭曲为椭圆形。在255天时将包膜取出进行组织学检查。在无涂层的对照组中，100%的植入物很早就形成了包膜。涂有两层经甲醛处理的胶原蛋白的组显示涂层覆盖的总表面积最大，包膜形成程度最低，挛缩率最低（7%），且发病时间最长。涂有单层经戊二醛处理的胶原蛋白的组显示涂层覆盖面积中等，包膜形成程度中等，挛缩率中等（50%），发病时间中等。这些观察结果通过显示完整的胶原蛋白涂层与无包膜形成之间的相关性证实了早期结果，并且还进一步证明了胶原蛋白涂层植入物的包膜挛缩率显著降低。
