Ksander G A, Vistnes L M
Ann Plast Surg. 1984 Jan;12(1):25-9. doi: 10.1097/00000637-198401000-00005.
Gel-filled miniprostheses were implanted in rats, recovered, and reimplanted in fresh animals. Experimental contracture characterized by severe, visually detectable distortion of hemispherical prosthesis mounds into pointed ovoid structures oriented laterally was observed. This finding confirms the existence in rats of a phenomenon similar in appearance to clinical contracture in humans. The incidence of contracture was higher than in the first implantation of these prostheses, which suggests that some property of the prosthesis is critical in the occurrence of contracture, and that this property can be altered by prolonged implantation in the tissue so that contracture is more likely. Implants that were overfilled by injection of extra fluid into the gel showed no contracture, but capsules around these implants did not differ from contracted capsules in protein, collagen, glycosaminoglycan composition, weight, thickness, histological appearance, or incidence of myofibroblasts.
将凝胶填充微型假体植入大鼠体内，取出后再植入新的动物体内。观察到实验性挛缩，其特征为半球形假体隆起严重变形，肉眼可见地变成侧向的尖卵形结构。这一发现证实大鼠体内存在一种外观与人类临床挛缩相似的现象。挛缩的发生率高于这些假体的首次植入，这表明假体的某些特性在挛缩的发生中至关重要，并且这种特性可因在组织中长时间植入而改变，从而使挛缩更易发生。通过向凝胶中注射额外液体而过度填充的植入物未出现挛缩，但这些植入物周围的包膜在蛋白质、胶原蛋白、糖胺聚糖组成、重量、厚度、组织学外观或肌成纤维细胞发生率方面与挛缩包膜并无差异。
