Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Division of Molecular Pathology, The Translational Genomics Research Institute/Ashion, Phoenix, Arizona, USA.
J Cutan Pathol. 2021 Jul;48(7):915-924. doi: 10.1111/cup.13984. Epub 2021 Mar 7.
"Cutaneous melanocytic tumor with CRTC1-TRIM11 fusion" (CMTCT) is a newly described, potentially novel entity that typically presents as a dermal nodule on the head and neck, extremities, and trunk of adults. Histopathologically, it is reported as a nodular or multinodular tumor composed of epithelioid and spindle cells that are variably immunoreactive for S100-protein, SOX10, and MITF along with more specific melanocytic markers such as MelanA and HMB45. With only 11 cases reported in the English literature so far, the neoplasm appears to behave in a relatively indolent fashion. Nevertheless, in one case, local recurrence and synchronous distant metastasis were evident after 13 years. Additional cases with longer follow-up are essential to determine the neoplasm's biologic behavior with more accuracy. Herein, two cases of CMTCT, one arising on the lower back of a 65-year-old female and the other on the arm of a 33-year-old female in addition to a comprehensive literature review are reported.
“CRTC1-TRIM11 融合相关性皮肤黑色素细胞肿瘤”（CMTCT）是一种新描述的、潜在的新型实体瘤，通常表现为成人头部、颈部、四肢和躯干的皮肤结节。组织病理学上，它被报道为一种结节性或多结节性肿瘤，由上皮样和梭形细胞组成，这些细胞对 S100 蛋白、SOX10 和 MITF 具有不同程度的免疫反应性，同时还具有更特异性的黑色素细胞标志物，如 MelanA 和 HMB45。到目前为止，在英文文献中仅报道了 11 例这种肿瘤，该肿瘤似乎表现出相对惰性的行为。然而，在一例患者中，在 13 年后出现了局部复发和同步远处转移。需要更多具有更长随访时间的病例来更准确地确定该肿瘤的生物学行为。本文报告了两例 CMTCT，一例发生在 65 岁女性的下背部，另一例发生在 33 岁女性的手臂上，并进行了全面的文献复习。
