Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
J Cutan Pathol. 2022 Dec;49(12):1025-1030. doi: 10.1111/cup.14287. Epub 2022 Aug 4.
Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity with only 13 cases reported in the literature. Histopathologically, the neoplasm consists of atypical epithelioid to spindled cells that form a well-circumscribed nodule usually confined to the dermis and subcutis with cytological features including large vesicular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity of melanocytic markers. Currently, there are limited data regarding long-term outcomes of this newly described entity. Most cases have done well, but there is one case reported with an adverse event. Hence, further studies are needed to accurately classify this tumor. Definitive diagnosis is made by laboratory evidence of CMCT. Herein, we report the first case of CMCT with epidermal involvement in the youngest patient known to be affected to date.
具有 CRTC1::TRIM11 融合的皮肤黑色素细胞肿瘤（CMCT）是一种最近描述的实体，文献中仅报道了 13 例。组织病理学上，该肿瘤由典型的上皮样至梭形细胞组成，通常形成界限清楚的结节，局限于真皮和皮下组织，细胞学特征包括大泡状核，核仁明显，嗜酸性细胞质丰富。免疫组织化学显示黑色素细胞标志物的可变表达性。目前，关于这种新描述的实体的长期结果的数据有限。大多数病例预后良好，但有一例报道有不良事件。因此，需要进一步的研究来准确分类这种肿瘤。通过实验室证据诊断明确。在此，我们报告首例 CMCT 病例，该患者为目前已知受影响的最年轻患者，伴表皮累及。
