Gladkova I N, Rusakov V F, Chernikov R A, Karelina Yu V, Nikitina T P, Efremov S M, Ionova T I
Saint Petersburg State University Hospital.
Probl Endokrinol (Mosk). 2021 Jan 19;67(1):41-51. doi: 10.14341/probl12714.
Quality of life (QoL) assessment before and after surgical treatment in patients with primary hyperparathyroidism (PHTP) may be useful for comprehensive evaluation of the treatment effect, as well as for monitoring of the patient' condition after surgery, including in real clinical practice.
The aim of the study was to validate and test the Russian version of the PHPQoL questionnaire for assessment of the quality of life (QoL) in patients with primary hyperparathyroidism (PHPT) for further application in clinical practice and research in Russia.
The linguistic and cultural adaptation of the PHPQoL questionnaire was carried out in accordance with international guidelines. Psychometric properties of the tool, namely, its reliability, validity and sensitivity were tested in the focus group of patients with PHPTResults: In the whole, 65 patients with PHPT were involved into the study (mean age - 52.3 ± 10.5 years, 97% - -women): 67.7% patients were symptomatic, 35.4% patients had moderate or severe hypercalcemia. All the patients filled out the Russian version of PHPQoL before parathyroidectomy. One third of patients filled out the Russian version of PHPQoL twice - before surgery and 3 months after surgery. Satisfactory external and content validity of the Russian version of PHPQoL was demonstrated. Its stable structure confirmed satisfactory construct validity of the questionnaire. The ability of the tool to determine differences in severity of symptoms/problems due to PHPT before and after treatment was revealed. The positive effect of the surgery on QoL in PHPT patients was shown.
The results obtained during the study confirm that the Russian version of PHPQoL is a reliable, valid and sensitive tool. Feasibility and applicability of its use in research and clinical practice in Russian endocrinology settings has been demonstrated.
原发性甲状旁腺功能亢进症（PHTP）患者手术治疗前后的生活质量（QoL）评估，对于全面评估治疗效果以及监测患者术后状况（包括在实际临床实践中）可能是有用的。
本研究的目的是验证和测试用于评估原发性甲状旁腺功能亢进症（PHPT）患者生活质量（QoL）的俄罗斯版PHPQoL问卷，以便在俄罗斯的临床实践和研究中进一步应用。
PHPQoL问卷的语言和文化适应性按照国际指南进行。在PHPT患者焦点小组中测试了该工具的心理测量特性，即其可靠性、有效性和敏感性。
总体而言，65例PHPT患者参与了研究（平均年龄 - 52.3±10.5岁，97%为女性）：67.7%的患者有症状，35.4%的患者有中度或重度高钙血症。所有患者在甲状旁腺切除术前填写了俄罗斯版的PHPQoL。三分之一的患者填写了两次俄罗斯版的PHPQoL——手术前和手术后3个月。俄罗斯版PHPQoL显示出令人满意的外部和内容效度。其稳定的结构证实了问卷具有令人满意的结构效度。该工具揭示了确定治疗前后PHPT导致的症状/问题严重程度差异的能力。显示了手术对PHPT患者QoL的积极影响。
研究期间获得的结果证实，俄罗斯版的PHPQoL是一种可靠、有效且敏感的工具。已证明其在俄罗斯内分泌学环境的研究和临床实践中的可行性和适用性。
