Özgüven Salih, Filizoğlu Nuh, Kesim Selin, Öksüzoğlu Kevser, Şen Feyza, Öneş Tunç, İnanır Sabahat, Turoğlu Halil Turgut, Erdil Tanju Yusuf
Marmara University Pendik Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey.
Mol Imaging Radionucl Ther. 2021 Feb 9;30(1):39-46. doi: 10.4274/mirt.galenos.2021.37268.
Somatostatin is an endocrine peptide hormone that regulates neurotransmission and cell proliferation by interacting with G protein-coupled somatostatin receptors (SSTRs). SSTRs are specific molecular targets of several radiotracers for neuroendocrine tumor (NET) imaging. Gallium-68 (Ga)-DOTA-TATE is widely used for positron emission tomography/computed tomography (PET/CT) imaging of SSTRs and has shown a higher affinity for SSTR2, the most common SSTR subtype found in NETs. We aimed to analyze the distribution pattern of Ga-DOTA-TATE in normal subjects.
A total of 617 consecutive Ga-DOTA-TATE PET/CT whole-body scans performed in our department from May 2015 through April 2020 with known or suspected neuroendocrine malignancies, mostly to evaluate adrenal adenomas, were retrospectively analyzed by 2 nuclear medicine physicians. One hundred eighteen subjects without a diagnosis of NET, with no tracer avid lesion of NET on Ga-DOTA-TATE PET/CT, and followed up for at least 6 months (average 2-3 years) without any biochemical, clinical, or imaging findings suggestive of NET were included in this study.
The highest uptake of Ga-DOTA-TATE was noted in the spleen followed by the kidneys, adrenal glands, liver, stomach, small intestine, prostate gland, pancreas head, pancreas body, thyroid gland, and uterus, in descending order. Minimal to mild uptake was detected in the submandibular glands, parotid glands, thymus, muscles, bones, breast, lungs, and mediastinum.
Our study shows the biodistribution pattern of Ga-DOTA-TATE in normal subjects and the ranges of the maximum standard uptake value (SUV) and SUV values of 68Ga-DOTA-TATE obtained in several tissues for reliably identifying malignancy in Ga-DOTA-TATE PET/CT studies.
生长抑素是一种内分泌肽激素，通过与G蛋白偶联生长抑素受体（SSTRs）相互作用来调节神经传递和细胞增殖。SSTRs是几种用于神经内分泌肿瘤（NET）成像的放射性示踪剂的特定分子靶点。镓-68（Ga）-DOTA-TATE被广泛用于SSTRs的正电子发射断层扫描/计算机断层扫描（PET/CT）成像，并且对SSTR2显示出更高的亲和力，SSTR2是NETs中最常见的SSTR亚型。我们旨在分析Ga-DOTA-TATE在正常受试者中的分布模式。
对2015年5月至2020年4月在我们科室进行的共617例连续的Ga-DOTA-TATE PET/CT全身扫描进行回顾性分析，这些扫描对象患有已知或疑似神经内分泌恶性肿瘤，主要用于评估肾上腺腺瘤，由2名核医学医师进行分析。本研究纳入了118名未诊断为NET的受试者，他们在Ga-DOTA-TATE PET/CT上没有NET的示踪剂摄取性病变，并且随访至少6个月（平均2 - 3年），没有任何提示NET的生化、临床或影像学表现。
Ga-DOTA-TATE摄取最高的部位是脾脏，其次是肾脏、肾上腺、肝脏、胃、小肠、前列腺、胰头、胰体、甲状腺和子宫，按降序排列。在颌下腺、腮腺、胸腺、肌肉、骨骼、乳腺、肺和纵隔中检测到最小到轻度摄取。
我们的研究显示了Ga-DOTA-TATE在正常受试者中的生物分布模式，以及在几个组织中获得的68Ga-DOTA-TATE的最大标准摄取值（SUV）和SUV值范围，以便在Ga-DOTA-TATE PET/CT研究中可靠地识别恶性肿瘤。
