Han Shin Ae, Ryu Jeongryul, Song Sang Woo, Kim Jae-Seung, Ryu Jin-Sook, Oh Minyoung
Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505 Republic of Korea.
Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Nucl Med Mol Imaging. 2024 Aug;58(5):310-316. doi: 10.1007/s13139-024-00854-5. Epub 2024 Feb 23.
We present the case of a 70-year-old male patient who underwent a gallium-68 (Ga)-DOTATOC brain positron emission tomography (PET)/computed tomography (CT) for the assessment of a tumorous lesion on the dura. The patient had previously undergone below-knee amputation due to a mass of synovial sarcoma on the left foot and completed adjuvant chemotherapy approximately 3 months ago. Subsequently, a well-demarcated papillary solid mass located on the dura was surgically excised. Pathological examination confirmed that the dural metastasis originated from synovial sarcoma and post-operative magnetic resonance imaging (MRI) revealed no residual tumor. We conducted a Ga-DOTATOC brain PET/CT suspecting a meningioma given the presence of a dural mass. The result showed lower uptake (maximum standardized uptake [SUV 4.9]) than the pituitary gland (SUV 9.3). Thus, we successfully conducted a differential diagnosis of metastasis from the preexisting malignancy rather than the meningioma. Ga-DOTATOC PET/CT is a valuable tool for the differential diagnosis of meningioma. However, metastasis should also be considered, especially in patients with a history of malignancy and lesions showing mild Ga-DOTATOC uptake.
我们报告一例70岁男性患者,该患者接受了镓-68(Ga)-DOTATOC脑正电子发射断层扫描(PET)/计算机断层扫描(CT),以评估硬脑膜上的肿瘤性病变。该患者此前因左足部滑膜肉瘤肿块接受了膝下截肢手术,并于约3个月前完成了辅助化疗。随后,手术切除了位于硬脑膜上的一个边界清晰的乳头状实性肿块。病理检查证实硬脑膜转移瘤起源于滑膜肉瘤,术后磁共振成像(MRI)显示无残留肿瘤。鉴于存在硬脑膜肿块,我们对该患者进行了Ga-DOTATOC脑PET/CT检查,怀疑为脑膜瘤。结果显示该肿块的摄取低于垂体(最大标准化摄取值[SUV 4.9]对比垂体SUV 9.3)。因此,我们成功地对该病例进行了鉴别诊断,确定其为先前存在的恶性肿瘤转移而非脑膜瘤。Ga-DOTATOC PET/CT是鉴别脑膜瘤的一种有价值的工具。然而,尤其是对于有恶性肿瘤病史且病变表现为Ga-DOTATOC摄取轻度的患者,也应考虑转移瘤的可能性。