Department of Psychiatry & Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, USA.
Department of Family and Community Medicine, University of Texas Health Science Center at Houston, Houston, USA.
J Psychopharmacol. 2021 May;35(5):611-614. doi: 10.1177/0269881121991566. Epub 2021 Feb 14.
The response time speed-accuracy trade-off (SATO) is an established index of information processing ability, but rarely examined as a variable in association with treatment of substance use disorder (SUD).
The purpose of this study was to test baseline information-processing ability differences between individuals who respond to treatment for cocaine use disorder v. those who do not.
Eighty patients enrolled in a clinical trial for cocaine use disorder completed a baseline drug-specific eye-tracking (anti-saccade) assessment prior to treatment, which included trials with both cocaine-related and neutral stimuli. SATO functions were computed for treatment responders v. non-responders.
Unexpectedly, responders demonstrated statistically different SATO functions, showing poorer accuracy when executing faster response times. This difference was present on trials that presented cocaine stimuli only.
SATO during performance of an eye-movement task may be useful for predicting differential response to substance use disorder treatment. However, in the present study, results were specific to cocaine cues rather than an overall SATO performance decrement.
反应时速度-准确性权衡（SATO）是一种既定的信息处理能力指标，但很少作为变量与物质使用障碍（SUD）的治疗相关联进行检查。
本研究的目的是测试在可卡因使用障碍治疗中对治疗有反应的个体与无反应的个体之间的基线信息处理能力差异。
80 名参加可卡因使用障碍临床试验的患者在治疗前完成了基线药物特异性眼动（反扫视）评估，其中包括使用可卡因相关和中性刺激的试验。为治疗反应者和非反应者计算了 SATO 函数。
出乎意料的是，反应者表现出统计学上不同的 SATO 函数，在执行更快的反应时间时准确性较差。这种差异仅存在于呈现可卡因刺激的试验中。
在执行眼球运动任务时的 SATO 可能有助于预测物质使用障碍治疗的反应差异。然而，在本研究中，结果仅针对可卡因线索，而不是整体 SATO 表现下降。
