Department of Microbiology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Infect Dis. 2021 Feb 15;223(12 Suppl 2):38-45. doi: 10.1093/infdis/jiaa223.
HIV-infected individuals successfully controlling viral replication via antiretroviral therapy often have a compromised HIV-specific T-cell immune response due to the lack of CD4 T-cell help, viral escape, T-cell exhaustion, and reduction in numbers due to the withdrawal of cognate antigen. A successful HIV cure strategy will likely involve a durable and potent police force that can effectively recognize and eliminate remaining virus that may emerge decades after an individual undergoes an HIV cure regimen. T cells are ideally suited to serve in this role, but given the state of the HIV-specific T-cell response, it is unclear how to best restore HIV-specific T-cell activity prior initiation of a HIV cure strategy. Here, we review several strategies of generating HIV-specific T cells ex vivo that are currently being tested in the clinic and discuss how infused T cells can be part of an HIV cure strategy.
通过抗逆转录病毒疗法成功控制病毒复制的 HIV 感染者，由于缺乏 CD4 T 细胞辅助、病毒逃逸、T 细胞耗竭以及由于同源抗原的撤回导致数量减少，往往会导致 HIV 特异性 T 细胞免疫反应受损。成功的 HIV 治愈策略可能需要一个持久而有效的警察部队，该部队能够有效地识别和消除个体接受 HIV 治愈方案几十年后可能出现的剩余病毒。T 细胞是最适合担任这一角色的细胞，但鉴于 HIV 特异性 T 细胞反应的状态，目前尚不清楚在启动 HIV 治愈策略之前如何最好地恢复 HIV 特异性 T 细胞活性。在这里，我们回顾了几种目前正在临床中测试的体外生成 HIV 特异性 T 细胞的策略，并讨论了输注的 T 细胞如何成为 HIV 治愈策略的一部分。
