Aichi Medical University, Nagakute, Japan.
Fujisawa City Hospital, Fujisawa, Japan.
Int J Lab Hematol. 2021 Oct;43(5):948-958. doi: 10.1111/ijlh.13486. Epub 2021 Feb 15.
While white blood cell (WBC) parameters have been suggested to depend on ethnicity and gender, reference intervals in healthy Asian populations are limited. The present study established reference intervals of WBC parameters for healthy adults in Japan.
A total of 750 healthy adults (447 women and 303 men; 18-67 years old, median 40 years old) at 7 Japanese centers who participated in regular medical checkups entered this study. The WBC parameters were measured using automated hematocytometers and blood film reviews by a manual microscopic examination.
The reference intervals of the WBC parameters according to gender in healthy adults were determined. Age-specific decreases in WBC counts of both gender groups and in neutrophil counts of women were noted. Favorable correlations between the hematocytometer and microscopic methods were found in neutrophils, lymphocytes, and eosinophils but not in monocytes or basophils.
This study suggests the need to consider gender and age in the clinical use of reference intervals of WBC parameters.
虽然白细胞（WBC）参数被认为与种族和性别有关，但健康亚洲人群的参考区间有限。本研究旨在为日本健康成年人建立 WBC 参数的参考区间。
本研究共纳入 7 个日本中心的 750 名健康成年人（女性 447 名，男性 303 名；年龄 18-67 岁，中位年龄 40 岁），他们均参加了常规体检。使用自动血细胞计数器测量 WBC 参数，并通过手动显微镜检查进行血涂片复查。
确定了健康成年人按性别划分的 WBC 参数参考区间。观察到两性组的 WBC 计数和女性中性粒细胞计数随年龄的特异性下降。在中性粒细胞、淋巴细胞和嗜酸性粒细胞中，血细胞计数器法与显微镜法之间存在良好的相关性，但在单核细胞和嗜碱性粒细胞中则没有。
本研究提示在临床应用 WBC 参数参考区间时需考虑性别和年龄因素。
