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向前发展:完全体外孕育面临的一个问题。

Moving forwards: A problem for full ectogenesis.

作者信息

Baron Teresa

机构信息

Institute of Philosophy, Czech Academy of Sciences, Praha, Czech Republic.

出版信息

Bioethics. 2021 Jun;35(5):407-413. doi: 10.1111/bioe.12848. Epub 2021 Feb 15.

Abstract

Most existing literature on the ethics of full ectogenesis has proceeded under the presupposition that science will at some point produce sophisticated technologies for full-term gestation (from embryo to infant) outside the human womb, delivering neonate health outcomes comparable with (or even superior to) biological gestation. However, the development of this technology-as opposed to the support systems currently being advanced-would require human subject experiments in embryo-onwards development using ectogenic prototypes. Literature on ectogenic research ethics has so far focused on 'backwards' development of partial ectogenesis: incubation and ectogestation technologies that would allow the support of earlier and earlier neonates and foetuses. However, little has been said about the ethics of 'forwards' development of (partial or full) ectogenesis, involving the development of embryos and foetuses in prototype environments. Such a prototype might allow us to produce a gestateling or live neonate from a human embryo, but with poorer expected development and health outcomes than from biological gestation; it might also produce only gestatelings (healthy or otherwise) before the technology was developed to a stage where full-term gestation was achievable. This paper explicates some of the ethical issues that this raises for the development of 'full' ectogenesis, and presents prima facie reasons to consider this research problematic and therefore to require extensive further argument in its defence.

摘要

大多数关于完全体外孕育伦理的现有文献都是在这样的预设下进行的

即科学在某个时候将开发出用于在人体子宫外进行足月妊娠(从胚胎到婴儿)的复杂技术,使新生儿的健康结果与生物妊娠相当(甚至更优)。然而,与目前正在推进的支持系统不同,这项技术的开发需要使用体外孕育原型对胚胎发育直至婴儿阶段进行人体实验。关于体外孕育研究伦理的文献目前主要集中在部分体外孕育的“逆向”发展:即孕育和体外妊娠技术,这些技术能够支持越来越早阶段的新生儿和胎儿。然而,对于(部分或完全)体外孕育“正向”发展的伦理,也就是在原型环境中胚胎和胎儿发育方面,却很少有人提及。这样一个原型可能使我们能够从人类胚胎中培育出一个妊娠体或活体新生儿,但预期发育和健康结果比生物妊娠要差;在该技术发展到能够实现足月妊娠的阶段之前,它也可能只能培育出妊娠体(无论健康与否)。本文阐述了这种情况给“完全”体外孕育发展带来的一些伦理问题,并提出初步理由认为这项研究存在问题,因此需要进行大量进一步论证来为其辩护。

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