Watson D, Noble M J, Dutton G N, Midgley J M, Healey T M
Department of Pharmacy, University of Strathclyde, Glasgow, Scotland.
Arch Ophthalmol. 1988 May;106(5):686-7. doi: 10.1001/archopht.1988.01060130748037.
Gas chromatography combined with mass spectrometry was used to determine the absorption of topically applied dexamethasone alcohol into the aqueous humor of human subjects undergoing routine intraocular surgery. The dexamethasone concentration in aqueous humor was greatest in the interval between 91 and 120 minutes following instillation (mean concentration, 31 ng/mL). Dexamethasone was still detectable in the aqueous 12 hours after instillation.
采用气相色谱-质谱联用技术测定常规眼科手术患者局部应用地塞米松酒精后房水中的吸收情况。滴入药物后91至120分钟内房水中地塞米松浓度最高（平均浓度为31纳克/毫升）。滴入药物12小时后房水中仍可检测到地塞米松。
