López-Farré A, Torralbo M, López-Novoa J M
Laboratory of Renal Physiopathology, Fundación Jiménez Diaz-CSIC, Madrid, Spain.
Biochem Biophys Res Commun. 1988 Apr 15;152(1):129-35. doi: 10.1016/s0006-291x(88)80689-2.
The production of Platelet Activating Factor (PAF-acether) by glomeruli isolated from rats subjected to a 60 min renal ischemia has been studied. PAF-acether has been purified by Sep-Pak columns and measured by its ability to release serotonin from previously loaded rabbit platelets. Glomeruli from ischemic kidneys had higher amounts of PAF-acether activity than glomeruli from sham operated rats. These data suggest a role for PAF-acether in the renal functional alterations induced by renal ischemia.
对从经历60分钟肾脏缺血的大鼠分离出的肾小球产生血小板活化因子（PAF-乙醚）的情况进行了研究。PAF-乙醚已通过Sep-Pak柱纯化，并通过其从预先加载的兔血小板中释放血清素的能力进行测定。缺血肾脏的肾小球比假手术大鼠的肾小球具有更高的PAF-乙醚活性。这些数据表明PAF-乙醚在肾脏缺血诱导的肾功能改变中起作用。
