Department of Biomedical Sciences, Mercer University School of Medicine, 1501 Mercer University Drive, Macon, GA, 31207, USA.
Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536-0298, USA.
Neurosci Lett. 2021 Mar 23;748:135719. doi: 10.1016/j.neulet.2021.135719. Epub 2021 Feb 12.
Transient Receptor Potential (TRP) channels expressed in specific subsets of airway sensory nerves function as transducers and integrators of a diverse range of sensory inputs including chemical, mechanical and thermal signals. These TRP sensors can detect inhaled irritants as well as endogenously released chemical substances. They play an important role in generating the afferent activity carried by these sensory nerves and regulating the centrally mediated pulmonary defense reflexes. Increasing evidence reported in recent investigations has revealed important involvements of several TRP channels (TRPA1, TRPV1, TRPV4 and TRPM8) in the manifestation of various symptoms and pathogenesis of certain acute and chronic airway diseases. This mini-review focuses primarily on these recent findings of the responses of these TRP sensors to the biological stresses emerging under the pathophysiological conditions of the lung and airways.
瞬时受体电位 (TRP) 通道表达在特定的气道感觉神经亚群中，作为各种感觉输入的传感器和整合器，包括化学、机械和热信号。这些 TRP 传感器可以检测吸入的刺激物以及内源性释放的化学物质。它们在产生这些感觉神经携带的传入活动和调节中枢介导的肺防御反射方面发挥重要作用。最近的研究报告了越来越多的证据，揭示了几种 TRP 通道（TRPA1、TRPV1、TRPV4 和 TRPM8）在某些急性和慢性气道疾病的各种症状和发病机制中的重要作用。这篇综述主要关注这些 TRP 传感器对肺和气道病理生理条件下出现的生物应激的反应的最新发现。
