Clinical Medicine, Senior Students from the Southwest Medical University, Luzhou 646000, Sichuan, PR China.
Department of Gastroenterology, Luzhou People's Hospital, Luzhou 646000, Sichuan, PR China.
Int Immunopharmacol. 2021 May;94:107454. doi: 10.1016/j.intimp.2021.107454. Epub 2021 Feb 12.
The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with the severity of Henoch-Schonlein purpura (HSP). Therefore, we conducted a meta-analysis to evaluate the clinical significance of NLR and PLR in HSP and its complications.
A comprehensive literature search was conducted by searching the PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang, VIP, and SinoMed databases from their inception to September 31, 2020. We used the standard mean difference (SMD) with a 95% confidence interval (CI) to estimate the pooled effect and used subgroup analysis to investigate heterogeneity.
A total of 1,691 HSP patients and 563 healthy controls (HCs) from 15 studies were included in the analysis. The NLR value was significantly higher in 431 HSP patients with gastrointestinal complications (HSP-GCs) than that in 833 HSP patients without GCs (SMD = 1.09, 95% CI: 0.62-1.57, P < 0.001); in 83 HSP adult patients with renal involvement (HSP-RI) than that in 131 adult HSP patients without RI (SMD = 0.33, 95% CI: 0.05-0.60, P = 0.021); and in 831 HSP patients than that in 563 HCs (SMD = 0.70, 95% CI: 0.51-0.89, P < 0.001). The PLR was significantly higher in 417 HSP patients than that in 264 HCs (SMD = 0.39, 95% CI: 0.06-0.71, P = 0.02).
NLR could serve as a useful biomarker to predict GCs and RI in patients with HSP. However, further well-designed and large cohort studies are warranted to confirm these findings.
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）与过敏性紫癜（HSP）的严重程度相关。因此，我们进行了一项荟萃分析，以评估 NLR 和 PLR 在 HSP 及其并发症中的临床意义。
通过检索 PubMed、EMBASE、Web of Science、Cochrane 图书馆、中国知网、万方、维普和中国生物医学文献数据库，从建库至 2020 年 9 月 31 日，全面检索 NLR 和 PLR 与 HSP 及其并发症相关的文献。采用标准均数差（SMD）及其 95%置信区间（CI）来评估汇总效应，并采用亚组分析来探讨异质性。
共纳入 15 项研究的 1691 例 HSP 患者和 563 例健康对照者（HCs）。431 例 HSP 合并胃肠道并发症（HSP-GC）患者的 NLR 值明显高于 833 例无 GC 的 HSP 患者（SMD=1.09，95%CI：0.62-1.57，P<0.001）；83 例 HSP 合并肾损害（HSP-RI）成年患者的 NLR 值明显高于 131 例无 RI 的 HSP 成年患者（SMD=0.33，95%CI：0.05-0.60，P=0.021）；831 例 HSP 患者的 NLR 值明显高于 563 例 HCs（SMD=0.70，95%CI：0.51-0.89，P<0.001）。417 例 HSP 患者的 PLR 值明显高于 264 例 HCs（SMD=0.39，95%CI：0.06-0.71，P=0.02）。
NLR 可作为预测 HSP 患者发生 GC 和 RI 的有用生物标志物。然而，还需要进一步进行设计良好、大样本队列研究来证实这些发现。
