中性粒细胞与淋巴细胞比值及平均血小板体积在过敏性紫癜相关胃肠道和肾脏受累中的预测作用。
Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement.
作者信息
Yakut Halil I, Kurt Tuba, Uncu Nermin, Semsa Cayci F, Celikel Acar Banu
机构信息
Department of Pediatrics, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
出版信息
Arch Argent Pediatr. 2020 Apr;118(2):139-142. doi: 10.5546/aap.2020.eng.139.
BACKGROUND
Henoch-Schönlein purpura (HSP) is a systemic small-vessel vasculitis that occurs mainly in children. The aim was to evaluate the blood neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with HSP and to investigate the relationship with gastrointestinal and renal involvement.
METHODS
Children with HSP and healthy individuals as controls were included. Hemoglobin level, white blood cell count, platelet count, NLR, MPV erythrocyte sedimentation rate and C-reactive protein were evaluated.
RESULTS
There were 71 HSP children and 74 controls. NLR was significantly higher in HSP patients with gastrointestinal bleeding than without gastrointestinal bleeding (p < 0,001). The optimal cutoff value of NLR for predicting gastrointestinal bleeding was 2.05, with 93 % sensitivity and 62 % specificity. MPV was significantly higher in HSP patients with renal involvement than without renal involvement (p = 0,027).
CONCLUSIONS
Blood NLR and MPV may be useful markers to identify gastrointestinal and renal involvement in HSP patients.
背景
过敏性紫癜（HSP）是一种主要发生于儿童的系统性小血管炎。目的是评估HSP患者的血液中性粒细胞与淋巴细胞比值（NLR）及平均血小板体积（MPV），并探讨其与胃肠道及肾脏受累情况的关系。
方法
纳入HSP患儿及健康个体作为对照。评估血红蛋白水平、白细胞计数、血小板计数、NLR、MPV、红细胞沉降率及C反应蛋白。
结果
HSP患儿71例，对照74例。有胃肠道出血的HSP患者NLR显著高于无胃肠道出血者（p < 0.001）。预测胃肠道出血的NLR最佳截断值为2.05，敏感性为93%，特异性为62%。有肾脏受累的HSP患者MPV显著高于无肾脏受累者（p = 0.027）。
结论
血液NLR和MPV可能是识别HSP患者胃肠道及肾脏受累情况的有用指标。
Zotero 插件