Wesierska M, Buresová O, Bures J
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Behav Brain Res. 1988 Feb;27(2):115-21. doi: 10.1016/0166-4328(88)90037-x.
The effect of paradoxical sleep deprivation (PSD) on subsequent acquisition of conditioned taste aversion (CTA) to liquid diets is confounded by the uncertain level of thirst when using the water tank procedure. This difficulty is eliminated when examining CTA and attenuation of neophobia (AN) to solid diets. Adult male rats (n = 100) were habituated to receive their daily ration of food during a 30-min stay in a box equipped with a row of 10 feeders baited with 2-3 g pieces of moist standard diet. 24-h PSD increased neophobic rejection of novel sweet food (with added 5% saccharose), but did not influence intensity of CTA elicited by LiCl poisoning. Addition of a bitter tasting red food dye to the sweet food caused marked neophobia which was enhanced by preceding PSD. Association of this unpalatable food with LiCl elicited strong CTA which extinguished faster in the PSD-pretreated animals. On the other hand, preacquisition PSD did not influence AN to the same stimulus. Sweet food with added blue dye elicited only mild neophobia which was enhanced by preceding 24-h PSD. Preacquisition PSD did not influence AN but significantly increased CTA to blue sweet food. It is concluded that PSD can either enhance or weaken CTA and that this complex effect on food selection learning cannot be explained by PSD-induced reduction of fear.
使用水箱法时，矛盾睡眠剥夺（PSD）对随后获得液体饮食条件性味觉厌恶（CTA）的影响因口渴程度不确定而混淆。在研究对固体饮食的CTA和新事物恐惧症减弱（AN）时，这个难题得以消除。成年雄性大鼠（n = 100）习惯于在一个装有一排10个喂食器的盒子里呆30分钟，喂食器中装有2 - 3克潮湿标准饮食块，以此获取每日定量食物。24小时的PSD增加了对新型甜味食物（添加5%蔗糖）的新事物恐惧性排斥，但不影响氯化锂中毒引发的CTA强度。在甜味食物中添加苦味红色食用色素会引起明显的新事物恐惧症，且在之前经历过PSD的情况下会增强。这种难吃的食物与氯化锂关联会引发强烈的CTA，且在经过PSD预处理的动物中消退得更快。另一方面，获取前的PSD对相同刺激的AN没有影响。添加蓝色染料的甜味食物仅引起轻微的新事物恐惧症，且在之前经历过24小时PSD的情况下会增强。获取前的PSD对AN没有影响，但显著增加了对蓝色甜味食物的CTA。结论是，PSD既可以增强也可以减弱CTA，且这种对食物选择学习的复杂影响不能用PSD引起的恐惧减少来解释。
