Bui Thanh Tung, Nguyen Thanh Hai
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J Basic Clin Physiol Pharmacol. 2017 Sep 26;28(5):413-423. doi: 10.1515/jbcpp-2016-0147.
Alzheimer's disease (AD) is related to increasing age. It is mainly characterized by progressive neurodegenerative disease, which damages memory and cognitive function. Natural products offer many options to reduce the progress and symptoms of many kinds of diseases, including AD. Meanwhile, natural compound structures, including lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids, have anti-inflammatory, antioxidant, anti-amyloidogenic, and anticholinesterase activities. In this review, we summarize the pathogenesis and targets for treatment of AD. We also present several medicinal plants and isolated compounds that are used for preventing and reducing symptoms of AD.
阿尔茨海默病（AD）与年龄增长有关。它主要以进行性神经退行性疾病为特征，会损害记忆和认知功能。天然产物为减轻包括AD在内的多种疾病的进展和症状提供了多种选择。同时，包括木脂素、黄酮类化合物、单宁、多酚、三萜、甾醇和生物碱在内的天然化合物结构具有抗炎、抗氧化、抗淀粉样蛋白生成和抗胆碱酯酶活性。在本综述中，我们总结了AD的发病机制和治疗靶点。我们还介绍了几种用于预防和减轻AD症状的药用植物和分离出的化合物。
