免疫检查点抑制剂相关的性腺功能减退和不育：免疫肿瘤学中的一个被忽视的问题。
Immune checkpoint inhibitor-related hypogonadism and infertility: a neglected issue in immuno-oncology.
机构信息
Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
International Cancer Prevention Institute, Lausanne, Switzerland.
出版信息
J Immunother Cancer. 2021 Feb;9(2). doi: 10.1136/jitc-2020-002220.
Abstract
Despite a significant amount of data on incidence and therapy of immune-related adverse events affecting virtually all organ systems, the potential impact of immune checkpoint inhibitors (ICIs) on gonadal function has not been sufficiently studied. The limited evidence available suggests that ICI-related primary hypogonadism due to orchitis as well as secondary hypogonadism due to hypophysitis are a potential risk for infertility. A systematic investigation of gonadal function under ICIs is warranted given the increasing application of ICIs in the adjuvant setting, among young adults and children and the possible influence of sex hormone levels on the efficacy and toxicity of ICIs.
摘要
尽管有大量关于影响几乎所有器官系统的免疫相关不良反应的发生率和治疗的数据，但免疫检查点抑制剂 (ICI) 对性腺功能的潜在影响尚未得到充分研究。现有有限的证据表明，ICI 相关性睾丸炎引起的原发性性腺功能减退症以及由于垂体炎引起的继发性性腺功能减退症是导致不孕的潜在风险。鉴于 ICI 在辅助治疗、年轻成人和儿童中的应用不断增加，以及性激素水平对 ICI 的疗效和毒性的可能影响，有必要对 ICI 下的性腺功能进行系统研究。
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