Kazimirskiĭ A N, Iarygin K N, Kositskiĭ G I, Rubina A Iu, Vinogradov V A
Biull Eksp Biol Med. 1988 Apr;105(4):424-6.
The dependence of ornithine decarboxylase (ODC) activity on hydra peptide morphogen doses has been established. The parameters of protein synthesis were determined in normal and regenerating rat liver, using the peptide in a dose of 20 micrograms/kg body weight, initiating maximum enzyme activity. It was established that intraperitoneal injection of the peptide in partially hepatectomized animals stimulated ODS activity in dose-dependent manner and was dome-shaped. The peptide injection in intact animals does not affect the intensity of 3H-leucine inclusion into the liver protein and the protein content in rat liver. However, the peptide injection in partially hepatectomized animals increased the level of 3H-leucine inclusion into the protein of regenerating liver and stimulated protein accumulation in this type of tissue.
已确定鸟氨酸脱羧酶（ODC）活性对水螅肽形态发生素剂量的依赖性。使用剂量为20微克/千克体重的该肽，在正常和再生大鼠肝脏中测定蛋白质合成参数，该剂量可引发最大酶活性。已确定，在部分肝切除的动物中腹腔注射该肽以剂量依赖性方式刺激ODS活性，且呈穹顶状。在完整动物中注射该肽不影响3H-亮氨酸掺入肝脏蛋白质的强度以及大鼠肝脏中的蛋白质含量。然而，在部分肝切除的动物中注射该肽可增加3H-亮氨酸掺入再生肝脏蛋白质中的水平，并刺激此类组织中的蛋白质积累。
