Cardoso Diogo N, Oliveira Miguel, Soares Amadeu M V M, Loureiro Susana
Department of Biology and Centre for Environmental and Marine Studies, University of Aveiro, Aveiro, Portugal.
Environ Toxicol Chem. 2022 Mar;41(3):592-600. doi: 10.1002/etc.5013. Epub 2021 Apr 23.
In realistic environmental scenarios, soil organisms can be exposed to a combination of pharmaceuticals and agriproducts or within different time frames. Therefore, it is necessary to increase knowledge on soil organism susceptibility under a complex mixture exposure scenario. The present study aimed to assess the susceptibility of the collembolan Folsomia candida to copper and dimethoate on a pre-exposure for 3 generations to human pharmaceuticals (fluoxetine and carbamazepine). Carryover effects on reproductive output and survival were observed after a multigenerational pre-exposure to carbamazepine or fluoxetine, considerably increasing the sensitivity of collembolans to both copper and dimethoate. This was more evident for collembolans pre-exposed to the highest concentrations of both pharmaceuticals (40 mg/kg soil), as demonstrated by a significant reduction in the number of juveniles and increased mortality. In addition, pre-exposure to carbamazepine and fluoxetine induced varying effects on subsequent exposure to the same chemical. Although pre-exposure to carbamazepine led to a decrease in collembolan reproduction, even when transferred to a clean medium, fluoxetine induced severe effects but only when collembolans were exposed to other contaminants (i.e., not when transferred to clean soil). The present study highlighted the need to consider carryover effects and possible interactions between pharmaceuticals and other contaminants under simultaneous exposure. Environ Toxicol Chem 2022;41:592-600. © 2021 SETAC.
在现实环境中，土壤生物可能会在不同时间段接触到药物和农产品的混合物。因此，有必要增加对复杂混合物暴露情况下土壤生物易感性的了解。本研究旨在评估在预先暴露于人类药物（氟西汀和卡马西平）3代的条件下，弹尾虫念珠弗索姆对铜和乐果的易感性。在多代预先暴露于卡马西平或氟西汀后，观察到对生殖产量和存活率的遗留效应，这大大增加了弹尾虫对铜和乐果的敏感性。对于预先暴露于两种药物最高浓度（40毫克/千克土壤）的弹尾虫来说，这种情况更为明显，表现为幼虫数量显著减少和死亡率增加。此外，预先暴露于卡马西平和氟西汀对随后接触相同化学物质产生了不同影响。虽然预先暴露于卡马西平会导致弹尾虫繁殖减少，即使转移到清洁介质中也是如此，但氟西汀仅在弹尾虫接触其他污染物时（即转移到清洁土壤中时不会）才会产生严重影响。本研究强调了在同时暴露情况下需要考虑遗留效应以及药物与其他污染物之间可能的相互作用。《环境毒理学与化学》2022年；41:592 - 600。© 2021 SETAC。
