Liu Jian-Cai, Wang Jie-Fei, Han Qing, Shangguan Ping, Liu Lu-Lu, Chen Li-Juan, Zhao Jun-Wei, Streb Carsten, Song Yu-Fei
Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan, 475004, China.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Angew Chem Int Ed Engl. 2021 May 10;60(20):11153-11157. doi: 10.1002/anie.202017318. Epub 2021 Apr 9.
The hierarchical aggregation of molecular nanostructures from multiple components is a grand synthetic challenge, which requires highly selective linkage control. We demonstrate how two orthogonal linkage groups, that is, organotin and lanthanide cations, can be used to drive the aggregation of a giant molecular metal oxide superstructure. The title compound {[(Sn(CH ) ) O] {[CeW O ] [TeW O ][CeSn(CH ) ] [TeW O ] } } (1 a) features dimensions of ca. 2.2×2.3×3.4 nm and a molecular weight of ca. 25 kDa. Structural analysis shows the hierarchical aggregation from several independent subunits. Initial biomedical tests show that 1 features an inhibitory effect on the proliferation of HeLa cells based on an apoptosis pathway. In vivo experiments in mice reveal the antiproliferative activity of 1 and open new paths for further development of this new compound class.
由多种组分构成的分子纳米结构的分级聚集是一项重大的合成挑战,这需要高度选择性的连接控制。我们展示了两种正交连接基团,即有机锡和镧系阳离子,如何用于驱动巨型分子金属氧化物超结构的聚集。标题化合物{[(Sn(CH ) ) O]{[CeW O ][TeW O ][CeSn(CH ) ][TeW O ] }} (1 a)的尺寸约为2.2×2.3×3.4 nm,分子量约为25 kDa。结构分析表明它由几个独立的亚基分级聚集而成。初步的生物医学测试表明,1基于凋亡途径对HeLa细胞的增殖具有抑制作用。在小鼠体内进行的实验揭示了1的抗增殖活性,并为这类新化合物的进一步开发开辟了新途径。