Department of Physical Chemistry, "Vinca" Institute of Nuclear Sciences, University of Belgrade, Belgrade 11,000, Serbia.
University Clinical Hospital Center dr Dragisa Misovic-Dedinje, Belgrade 11,000, Serbia.
Curr Med Chem. 2020;27(3):362-379. doi: 10.2174/0929867326666190827153532.
Polyoxometalates (POMs) are negatively charged metal-oxo clusters of early transition metal ions in high oxidation states (e.g., WVI, MoVI, VV). POMs are of interest in the fields of catalysis, electronics, magnetic materials and nanotechnology. Moreover, POMs were shown to exhibit biological activities in vitro and in vivo, such as antitumor, antimicrobial, and antidiabetic.
The literature search for this peer-reviewed article was performed using PubMed and Scopus databases with the help of appropriate keywords.
This review gives a comprehensive overview of recent studies regarding biological activities of polyoxometalates, and their biomedical applications as promising anti-viral, anti-bacterial, anti-tumor, and anti-diabetic agents. Additionally, their putative mechanisms of action and molecular targets are particularly considered.
Although a wide range of biological activities of Polyoxometalates (POMs) has been reported, they are to the best of our knowledge not close to a clinical trial or a final application in the treatment of diabetes or infectious and malignant diseases. Accordingly, further studies should be directed towards determining the mechanism of POM biological actions, which would enable fine-tuning at the molecular level, and consequently efficient action towards biological targets and as low toxicity as possible. Furthermore, biomedical studies should be performed on solutionstable POMs employing physiological conditions and concentrations.
多金属氧酸盐（POMs）是高氧化态（如 WVI、MoVI、VV）的早期过渡金属离子的带负电荷的金属-氧簇。POMs 在催化、电子、磁性材料和纳米技术等领域具有重要的应用价值。此外，研究表明 POMs 在体外和体内具有生物活性，如抗肿瘤、抗菌和抗糖尿病作用。
这篇同行评审文章的文献检索是在 PubMed 和 Scopus 数据库的帮助下使用适当的关键词进行的。
本综述全面概述了多金属氧酸盐的生物活性及其作为有前途的抗病毒、抗菌、抗肿瘤和抗糖尿病药物的生物医学应用的最新研究进展。此外，还特别考虑了它们潜在的作用机制和分子靶标。
尽管已经报道了多金属氧酸盐（POMs）的广泛的生物活性，但据我们所知，它们还没有接近临床试验或最终应用于治疗糖尿病或感染和恶性疾病。因此，应该进一步研究确定 POM 生物作用的机制，这将能够在分子水平上进行精细调整，从而有效地针对生物靶标，并尽可能降低毒性。此外，应该在生理条件和浓度下对溶液稳定的 POMs 进行生物医学研究。
