Department of Surgery and Emory Critical Care Center, Emory University, Atlanta, GA.
Department of Anesthesiology Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Italy.
Crit Care Med. 2021 Apr 1;49(4):598-622. doi: 10.1097/CCM.0000000000004895.
To identify research priorities in the management, pathophysiology, and host response of coronavirus disease 2019 in critically ill patients.
The Surviving Sepsis Research Committee, a multiprofessional group of 17 international experts representing the European Society of Intensive Care Medicine and Society of Critical Care Medicine, was virtually convened during the coronavirus disease 2019 pandemic. The committee iteratively developed the recommendations and subsequent document.
Each committee member submitted a list of what they believed were the most important priorities for coronavirus disease 2019 research. The entire committee voted on 58 submitted questions to determine top priorities for coronavirus disease 2019 research.
The Surviving Sepsis Research Committee provides 13 priorities for coronavirus disease 2019. Of these, the top six priorities were identified and include the following questions: 1) Should the approach to ventilator management differ from the standard approach in patients with acute hypoxic respiratory failure?, 2) Can the host response be modulated for therapeutic benefit?, 3) What specific cells are directly targeted by severe acute respiratory syndrome coronavirus 2, and how do these cells respond?, 4) Can early data be used to predict outcomes of coronavirus disease 2019 and, by extension, to guide therapies?, 5) What is the role of prone positioning and noninvasive ventilation in nonventilated patients with coronavirus disease?, and 6) Which interventions are best to use for viral load modulation and when should they be given?
Although knowledge of both biology and treatment has increased exponentially in the first year of the coronavirus disease 2019 pandemic, significant knowledge gaps remain. The research priorities identified represent a roadmap for investigation in coronavirus disease 2019.
确定危重症 2019 年冠状病毒病患者管理、发病机制和宿主反应方面的研究重点。
由 17 名国际专家组成的多专业幸存脓毒症研究委员会代表欧洲重症监护医学学会和重症监护医学学会，在 2019 年冠状病毒病大流行期间以虚拟方式召开会议。委员会对建议和后续文件进行了反复修订。
每位委员会成员提交一份他们认为 2019 年冠状病毒病最重要的研究重点清单。全体委员会对提交的 58 个问题进行投票，以确定 2019 年冠状病毒病研究的首要重点。
幸存脓毒症研究委员会为 2019 年冠状病毒病提供了 13 项研究重点。其中，确定了前六个重点，包括以下问题：1）呼吸机管理方法是否应与急性低氧性呼吸衰竭患者的标准方法有所不同？2）宿主反应能否通过治疗获益进行调节？3）严重急性呼吸综合征冠状病毒 2 直接靶向哪些特定细胞，这些细胞如何反应？4）早期数据能否用于预测 2019 年冠状病毒病的结局，并进一步指导治疗？5）俯卧位和无创通气在非通气 2019 年冠状病毒病患者中的作用如何？6）用于病毒载量调节的最佳干预措施是什么，以及何时给予？
尽管在 2019 年冠状病毒病大流行的第一年，生物学和治疗方面的知识呈指数级增长，但仍存在重大知识空白。确定的研究重点代表了 2019 年冠状病毒病研究的路线图。
