犬肾上腺髓质中共同释放的肽对儿茶酚胺分泌的抑制调节。
Inhibitory regulation by co-released peptides of catecholamine secretion by the canine adrenal medulla.
作者信息
Critchley J A, MacLean M R, Ungar A
机构信息
Department of Pharmacology, University of Edinburgh.
出版信息
Br J Pharmacol. 1988 Feb;93(2):383-6. doi: 10.1111/j.1476-5381.1988.tb11445.x.
Abstract
- We have stimulated the peripheral end of the cut left splanchnic nerve in anaesthetized dogs while collecting the venous effluent of the left adrenal gland for catecholamine estimation. 2. With low frequency stimulation the resting output of catecholamines was inhibited but at high frequencies it was augmented. 3. The inhibition of catecholamine output by low frequency stimulation was reversed by opiate antagonists (naloxone and nalmefene) but enhanced by angiotensin converting enzyme inhibitors (captopril and enalapril).
摘要
- 我们在麻醉犬身上刺激切断的左内脏神经的外周端，同时收集左肾上腺的静脉流出液以进行儿茶酚胺测定。2. 低频刺激时，儿茶酚胺的静息输出受到抑制，但高频刺激时则增加。3. 低频刺激对儿茶酚胺输出的抑制作用可被阿片拮抗剂（纳洛酮和纳美芬）逆转，但可被血管紧张素转换酶抑制剂（卡托普利和依那普利）增强。
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