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[海葵星状海葵,一种新兴的生物医学研究模型:机械敏感性、超强再生能力和长寿]

[The sea anemone Nematostella vectensis, an emerging model for biomedical research: Mechano-sensitivity, extreme regeneration and longevity].

作者信息

Amiel Aldine R, Michel Vincent, Carvalho João E, Shkreli Marina, Petit Christine, Röttinger Eric

机构信息

Université Côte d'Azur, CNRS, Inserm - Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), 06107 Nice, France - Université Côte d'Azur - Institut fédératif de recherche - ressources marines, 06107 Nice, France.

Institut de l'audition, Institut Pasteur, Inserm UMRS 1120, 75012 Paris, France.

出版信息

Med Sci (Paris). 2021 Feb;37(2):167-177. doi: 10.1051/medsci/2020282. Epub 2021 Feb 16.

Abstract

Nematostella has fascinating features such as whole-body regeneration, the absence of signs of aging and importantly, the absence of age-related diseases. Easy to culture and spawn, this little sea anemone in spite of its "simple" aspect, displays interesting morphological characteristics similar to vertebrates and an unexpected similarity in gene content/genome organization. Importantly, the scientific community working on Nematostella is developing a variety of functional genomics tools that enable scientists to use this anemone in the field of regenerative medicine, longevity and mecano-sensory diseases. As a complementary research model to vertebrates, this marine invertebrate is emerging and promising to dig deeper into those fields of research in an integrative manner (entire organism) and provides new opportunities for scientists to lift specific barriers that can be encountered with other commonly used animal models.

摘要

星状海葵具有一些迷人的特性,比如全身再生、没有衰老迹象,重要的是,没有与年龄相关的疾病。这种小海葵易于培养和繁殖,尽管外观“简单”,却展现出与脊椎动物相似的有趣形态特征,以及在基因含量/基因组组织方面出人意料的相似性。重要的是,研究星状海葵的科学界正在开发各种功能基因组学工具,使科学家能够在再生医学、长寿和机械感觉疾病领域利用这种海葵。作为脊椎动物的补充研究模型,这种海洋无脊椎动物正在兴起,并有望以综合方式(整个生物体)更深入地挖掘这些研究领域,为科学家突破其他常用动物模型可能遇到的特定障碍提供新机会。

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