Kendrick K M, Keverne E B, Chapman C, Baldwin B A
AFRC Institute of Animal Physiology and Genetics Research, Cambridge, U.K.
Brain Res. 1988 Jan 26;439(1-2):1-10. doi: 10.1016/0006-8993(88)91455-2.
Intracranial dialysis was used to measure the release of oxytocin (OXY), monoamines and their metabolites and uric acid (UA) from the substantia nigra (SN) and olfactory bulb (OB) of sheep during parturition, suckling, separation from lambs and eating. Results showed that OXY concentrations increased significantly during parturition, suckling and eating in the SN and during parturition and suckling in the OB. Concentrations of dopamine (DA) increased significantly in the SN during suckling and eating and in the OB during parturition and suckling. The dopamine metabolite, homovanillic acid, also increased significantly in the SN during parturition. Concentrations of the noradrenaline metabolite, 4-hydroxy-3-methoxyphenylethan-1,2-diol (MHPG) and the purine metabolite, UA, were significantly raised during parturition, suckling and separation from the lambs in the SN and increased UA levels were also found during eating. In a separate experiment it was confirmed that OXY was detectable in homogenates of both the SN and the OB. These results show that, in the sheep, OXY and DA release in the SN is associated with maternal and ingestive behaviour whereas similar release in the OB may only be related to maternal behaviour. Release of MHPG in the SN may be associated with maternal behaviour and/or stress.
采用颅内透析法，测定绵羊在分娩、哺乳、与羔羊分离及进食期间，催产素（OXY）、单胺及其代谢产物以及尿酸（UA）从黑质（SN）和嗅球（OB）的释放情况。结果显示，SN中OXY浓度在分娩、哺乳和进食期间显著升高，OB中则在分娩和哺乳期间显著升高。多巴胺（DA）浓度在SN中于哺乳和进食期间显著升高，在OB中于分娩和哺乳期间显著升高。多巴胺代谢产物高香草酸在SN中于分娩期间也显著升高。去甲肾上腺素代谢产物4-羟基-3-甲氧基苯乙二醇（MHPG）以及嘌呤代谢产物UA的浓度，在SN中于分娩、哺乳和与羔羊分离期间显著升高，进食期间UA水平也升高。在另一项实验中证实，SN和OB的匀浆中均可检测到OXY。这些结果表明，在绵羊中，SN中OXY和DA的释放与母性行为和摄食行为相关，而OB中类似的释放可能仅与母性行为有关。SN中MHPG的释放可能与母性行为和/或应激有关。
