铝暴露是否会影响认知功能？一项比较性横断面研究。
Does aluminum exposure affect cognitive function? a comparative cross-sectional study.
机构信息
Department of Public Health Surveillance and Advisory, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
Office, Cangnan Center for Disease Control and Prevention, Wenzhou, Zhejiang, China.
出版信息
PLoS One. 2021 Feb 16;16(2):e0246560. doi: 10.1371/journal.pone.0246560. eCollection 2021.
OBJECTIVES
This study assessed the cognitive function of aluminum-exposed participants from an alum mining zone, compared them with unexposed subjects, and aimed to elucidate the effect of aluminum exposure on cognition.
DESIGN
This was a comparative cross-sectional study. Univariate analyses were used to assess the differences between the aluminum-exposed and unexposed groups. Binary logistic regression models were applied to analyze the effect of aluminum exposure.
SETTING
The aluminum-exposed participants were included from an alum mining zone and the unexposed subjects were residents from another district without alum-mine-related factories.
PARTICIPANTS
We included 539 aluminum-exposed participants (254 men, 285 women) and 1720 unexposed participants (692 men, 1028 women).
RESULTS
The mean cognition score on Mini-Mental State Examination was 21.34 (± 6.81) for aluminum-exposed participants. The exposed group had 6.77 times (95% confidence interval, 5.09-9.00) more risk of cognitive impairment than the unexposed group, after adjusting for age, sex, and educational level. No statistically significant association was found between exposure duration and cognition.
CONCLUSIONS
This study demonstrated a significant association between aluminum exposure and lower cognitive function.
目的
本研究评估了来自铝矿区的铝暴露参与者的认知功能，将其与未暴露者进行比较，并旨在阐明铝暴露对认知的影响。
设计
这是一项比较性的横断面研究。单变量分析用于评估暴露组和未暴露组之间的差异。二元逻辑回归模型用于分析铝暴露的影响。
地点
暴露组参与者来自铝矿区，未暴露组参与者来自另一个没有与铝矿相关工厂的地区。
参与者
我们纳入了 539 名铝暴露参与者（254 名男性，285 名女性）和 1720 名未暴露参与者（692 名男性，1028 名女性）。
结果
铝暴露组参与者在简易精神状态检查中的平均认知评分为 21.34（±6.81）。在校正年龄、性别和教育水平后，暴露组认知障碍的风险是未暴露组的 6.77 倍（95%置信区间，5.09-9.00）。暴露时间与认知之间没有统计学上的显著关联。
结论
本研究表明铝暴露与较低的认知功能之间存在显著关联。
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