Austin M C, Kalivas P W
Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164-6520.
Brain Res. 1988 Feb 16;441(1-2):209-14. doi: 10.1016/0006-8993(88)91400-x.
The present study was designed to investigate the effect of cholinergic stimulation of the nucleus accumbens (NA) on locomotor behavior. Microinjection of the cholinergic agonist, carbachol, into the NA resulted in a dose-dependent increase in spontaneous locomotor activity. Pretreating rats with the nicotinic antagonist, mecamylamine, significantly reduced the carbachol-induced locomotor response, whereas pretreatment with the muscarinic antagonist, atropine, was ineffective. Injection of the dopamine antagonist, haloperidol, prior to stimulation of the NA with carbachol, significantly attenuated the motor stimulant effect of carbachol. Evidence has accumulated to suggest that the increased locomotor response elicited from NA stimulation is mediated by GABAergic efferents from the NA to the substantia innominata (SI). Pretreatment with the GABA agonist, muscimol, into the SI significantly antagonized the locomotor hyperactivity induced by carbachol injection into the NA. Taken together, these data indicate that carbachol produces a motor stimulant effect by activating nicotinic receptors which may modulate the release of dopamine in the NA and inhibit the GABAergic efferents to the SI.
本研究旨在探讨伏隔核（NA）胆碱能刺激对运动行为的影响。向NA微量注射胆碱能激动剂卡巴胆碱会导致自发运动活动呈剂量依赖性增加。用烟碱拮抗剂美加明预处理大鼠可显著降低卡巴胆碱诱导的运动反应，而用毒蕈碱拮抗剂阿托品预处理则无效。在用卡巴胆碱刺激NA之前注射多巴胺拮抗剂氟哌啶醇，可显著减弱卡巴胆碱的运动刺激作用。已有证据表明，NA刺激引起的运动反应增加是由NA向无名质（SI）的γ-氨基丁酸能传出神经介导的。向SI微量注射γ-氨基丁酸激动剂蝇蕈醇预处理可显著拮抗向NA注射卡巴胆碱所诱导的运动亢进。综上所述，这些数据表明，卡巴胆碱通过激活烟碱受体产生运动刺激作用，烟碱受体可能调节NA中多巴胺的释放，并抑制向SI的γ-氨基丁酸能传出神经。
