Slater P, Longman D A, Dickinson S L
Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(3):201-6. doi: 10.1007/BF00505486.
The effect of manipulating globus pallidus (GP) transmitters on the locomotor hyperactivity induced by administration of the dopamine agonist ADTN in the nucleus accumbens was investigated in rats with permanent intracerebral cannulae. Hyperactivity was antagonized by the GABA agonists muscimol and baclofen and the GABA antagonist bicuculline. Atropine, ADTN and ethylketazocine in GP had no effects on the response. Both morphine and the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine prevented the hyperactivity. The findings emphasize the role of GP GABA in the NA-induced hyperactivity and provide information about the functions of some other GP transmitters.
在永久性脑内插管的大鼠中，研究了操纵苍白球（GP）递质对伏隔核中多巴胺激动剂ADTN给药诱导的运动性多动的影响。GABA激动剂蝇蕈醇和巴氯芬以及GABA拮抗剂荷包牡丹碱可拮抗多动。GP中的阿托品、ADTN和依托唑啉对该反应无影响。吗啡和5-羟色胺激动剂5-甲氧基-N，N-二甲基色胺均可预防多动。这些发现强调了GP GABA在NA诱导的多动中的作用，并提供了有关其他一些GP递质功能的信息。
