Akema T, Hashimoto R, Kimura F
Department of Physiology, Yokohama City University School of Medicine, Japan.
Brain Res. 1988 Feb 16;441(1-2):367-70. doi: 10.1016/0006-8993(88)91416-3.
The microinjection of vasoactive intestinal peptide (VIP) into the medial preoptic area rapidly inhibited pulsatile luteinizing hormone (LH) secretion within 1 h in ovariectomized rats. A transient but significant increase in prolactin (PRL) secretion occurred after VIP injection coincidentally with the initiation of the inhibition of LH pulses. Preoptic microinjections of secretin or peptide histidine isoleucine amide (PHI) did not have such effects. These results suggest specific actions of VIP, despite its structural similarity to secretin and PHI, on the preoptic mechanisms governing LH and PRL secretion in ovariectomized rats.
向去卵巢大鼠的内侧视前区微量注射血管活性肠肽（VIP），1小时内可迅速抑制促黄体生成素（LH）的脉冲式分泌。注射VIP后，催乳素（PRL）分泌出现短暂但显著的增加，同时LH脉冲分泌开始受到抑制。视前区微量注射促胰液素或肽组氨酸异亮氨酸酰胺（PHI）则没有这种作用。这些结果表明，尽管VIP与促胰液素和PHI结构相似，但对去卵巢大鼠视前区调节LH和PRL分泌的机制具有特定作用。
